Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 4/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670123 | 0.88 | HIF1A (0.49) | HIF1ACCR2CCR5PNPALDH1A1 | |
| SCHEMBL9423837 | 0.86 | MAPT (0.38) | HIF1AALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8673156 | 0.80 | HIF1A (0.35) | HIF1ACCR2CCR5PNPALDH1A1 | |
| SCHEMBL8671011 | 0.78 | ACHE (0.45) | HIF1A | |
| SCHEMBL8979863 | 0.78 | AGTR2 (0.55) | — | |
| SCHEMBL1123369 | 0.77 | ALDH1A1 (0.52) | PNPALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8672211 | 0.75 | AGTR1 (0.49) | — | |
| SCHEMBL8979806 | 0.75 | — | — | |
| SCHEMBL8671888 | 0.74 | ACHE (0.49) | HIF1A | |
| SCHEMBL9205143 | 0.74 | CYP19A1 (0.39) | HIF1ACCR2CCR5ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804583-A | Pyrimidinone derivatives fused to nitrogen heterocycles having a II antagonistic activity | ISTITUTO LUSO FARMACO D'ITALIA (IT) | 1998-09-08 | — | — | US | disclosed |
| EP-0680480-B1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | LUSO FARMACO INST (IT) | 1997-07-30 | — | — | EP | disclosed |
| EP-0680480-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY. | LUSO FARMACO INST (IT) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994017067-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1994-08-04 | — | — | WO | disclosed |