Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 7/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | HEXA | P06865 | 3/20 | 0.41 |
| ▸ | HEXB | P07686 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8674616 | 0.82 | TERT (0.45) | TERTKEAP1NFE2L2TLR9HEXA | |
| SCHEMBL8670400 | 0.81 | HEXA (0.53) | KEAP1NFE2L2TLR9HEXAHEXB | |
| SCHEMBL8031989 | 0.78 | HEXA (0.69) | HEXAHEXBKDM4EMEN1ALDH1A1 | |
| SCHEMBL8664264 | 0.75 | KDM4E (0.58) | KEAP1NFE2L2TLR9HEXAHEXB | |
| SCHEMBL8672555 | 0.75 | MEN1 (0.54) | KEAP1NFE2L2TLR9HEXAHEXB | |
| SCHEMBL8669764 | 0.72 | MEN1 (0.60) | KEAP1NFE2L2TLR9HEXAHEXB | |
| SCHEMBL8670307 | 0.71 | CYP2D6 (0.61) | KEAP1NFE2L2TLR9HEXAHEXB | |
| SCHEMBL7614758 | 0.71 | GLS (0.55) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL8671682 | 0.70 | HEXA (0.71) | HEXAHEXBKDM4EMEN1ALDH1A1 | |
| SCHEMBL8668325 | 0.70 | HEXA (0.53) | HEXAHEXBKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789418-A | Bis-naphthalimides for the treatment of cancer | BASF AKTIENGESELLSCHAFT (DE) | 1998-08-04 | — | — | US | disclosed |