Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 12/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.58 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | RECQL | P46063 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL867430 | 0.87 | MAPT (0.63) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL18992075 | 0.79 | MAPT (0.58) | AURKAAURKBBACE1MAOAMAPT | |
| SCHEMBL4304001 | 0.77 | MAPT (0.74) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL29440907 | 0.77 | MAPT (0.74) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL29728494 | 0.77 | MAPT (0.72) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL5175867 | 0.77 | MAPT (0.72) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL4539611 | 0.74 | MALT1 (0.71) | BACE1MAOAMAPTKMT2AUSP2 | |
| SCHEMBL31290244 | 0.74 | MALT1 (0.71) | BACE1MAOAMAPTKMT2AUSP2 | |
| SCHEMBL24389157 | 0.74 | P4HB (0.64) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL16879551 | 0.74 | P4HB (0.64) | P4HBAURKAAURKBBACE1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498707-B1 | Process of dyeing keratinous fibers with a mono- or di-hydroxyindole and a non-oxidative aromatic carbonyl derivative and dyeing agent | OREAL (FR) | 1995-08-02 | — | — | EP | claimed |
| EP-0498707-A1 | Process of dyeing keratinous fibers with a mono- or di-hydroxyindole and a non-oxidative aromatic carbonyl derivative and dyeing agent | L'OREAL (FR) | 1992-08-12 | — | — | EP | claimed |
| US-10829427-B2 | Naphthoquinones, pro-drugs, and methods of use thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-11-10 | — | — | US | disclosed |
| US-10829427-B2 | Naphthoquinones, pro-drugs, and methods of use thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-11-10 | — | — | US | disclosed |
| US-20190071380-A1 | NAPHTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-03-07 | — | — | US | disclosed |
| US-20190071380-A1 | NAPHTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-03-07 | — | — | US | disclosed |
| WO-2017106624-A1 | NAPTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-06-22 | — | — | WO | disclosed |
| WO-2017106624-A1 | NAPTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-06-22 | — | — | WO | disclosed |
| EP-2436669-B1 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO LTD (JP) | 2016-01-13 | — | — | EP | disclosed |
| EP-2436669-B1 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO LTD (JP) | 2016-01-13 | — | — | EP | disclosed |
| US-8703979-B2 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO., LTD. (JP) | 2014-04-22 | — | — | US | disclosed |
| US-20090042977-A1 | Anticancer Compound, Intermediate Therefor, and Processes for Producing These | TAHEEBO JAPAN CO., LTD. (JP) | 2009-02-12 | — | — | US | disclosed |
| US-20090042977-A1 | Anticancer Compound, Intermediate Therefor, and Processes for Producing These | TAHEEBO JAPAN CO., LTD. (JP) | 2009-02-12 | — | — | US | disclosed |
| US-20080300415-A1 | Preparation of optically active 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4, 9-diones having anticancer activities | TAHEEBO JAPAN CO., LTD. (JP) | 2008-12-04 | — | — | US | disclosed |
| CN-101142202-A | Anticancer compound, intermediate therefor, and processes for producing these | TAHEEBO JAPAN KABUSHIKI KAISHA (JP) | 2008-03-12 | — | — | CN | disclosed |
| EP-1860103-A1 | ANTICANCER COMPOUND, INTERMEDIATE THEREFOR, AND PROCESSES FOR PRODUCING THESE | Taheebo Japan Co., Ltd. (JP) | 2007-11-28 | — | — | EP | disclosed |
| EP-1860103-A1 | ANTICANCER COMPOUND, INTERMEDIATE THEREFOR, AND PROCESSES FOR PRODUCING THESE | Taheebo Japan Co., Ltd. (JP) | 2007-11-28 | — | — | EP | disclosed |
| EP-0498707-B1 | Process of dyeing keratinous fibers with a mono- or di-hydroxyindole and a non-oxidative aromatic carbonyl derivative and dyeing agent | OREAL (FR) | 1995-08-02 | — | — | EP | disclosed |
| US-5275626-A | Hair dyes | L'OREAL (FR) | 1994-01-04 | — | — | US | disclosed |
| EP-0498707-A1 | Process of dyeing keratinous fibers with a mono- or di-hydroxyindole and a non-oxidative aromatic carbonyl derivative and dyeing agent | L'OREAL (FR) | 1992-08-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10829427-B2 | Naphthoquinones, pro-drugs, and methods of use thereof | NQO1, RECQL, ABCB1 | P4HB 2548/4885AURKA 1252/4885AURKB 692/4885 |
| US-20190071380-A1 | NAPHTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF | NQO1, RECQL, ABCB1 | P4HB 2548/4885AURKA 1252/4885AURKB 692/4885 |
| US-20080300415-A1 | Preparation of optically active 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4, 9-diones having anticancer activities | DUT, PARP15, NQO1 | P4HB 2763/4885AURKA 1376/4885AURKB 1641/4885 |
| US-20090042977-A1 | Anticancer Compound, Intermediate Therefor, and Processes for Producing These | NQO1, HADH, HADHB | P4HB 2246/4885AURKA 1226/4885AURKB 740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.