Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | RECQL | P46063 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | CASP1 | P29466 | 2/20 | 0.63 |
| ▸ | CDC25B | P30305 | 2/20 | 0.63 |
| ▸ | BLM | P54132 | 2/20 | 0.63 |
| ▸ | CASP7 | P55210 | 2/20 | 0.63 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL867967 | 0.87 | P4HB (0.58) | MAPTKDM4ERECQLKMT2AALDH1A1 | |
| SCHEMBL18992075 | 0.79 | MAPT (0.58) | MAPTKDM4ERECQLKMT2AALDH1A1 | |
| Plumbagin SCHEMBL29386213 | 0.77 | MAPT (1.00) | MAPTKDM4ERECQLKMT2AALDH1A1 | |
| Plumbagin SCHEMBL34186 | 0.77 | MAPT (1.00) | MAPTKDM4ERECQLKMT2AALDH1A1 | |
| SCHEMBL29405399 | 0.77 | MAPT (0.72) | MAPTKDM4ERECQLKMT2AALDH1A1 | |
| SCHEMBL109904 | 0.77 | MAPT (0.72) | MAPTKDM4ERECQLKMT2AALDH1A1 | |
| SCHEMBL30594079 | 0.77 | MAPT (0.63) | MAPTKDM4ERECQLKMT2AALDH1A1 | |
| Plumbagin SCHEMBL27811730 | 0.76 | MAPT (0.96) | MAPTKDM4ERECQLKMT2AALDH1A1 | |
| SCHEMBL31290244 | 0.74 | MALT1 (0.71) | MAPTKMT2AALDH1A1MAPK1MEN1 | |
| SCHEMBL4539611 | 0.74 | MALT1 (0.71) | MAPTKMT2AALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2436669-B1 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO LTD (JP) | 2016-01-13 | — | — | EP | disclosed |
| EP-2436669-B1 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO LTD (JP) | 2016-01-13 | — | — | EP | disclosed |
| US-8703979-B2 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO., LTD. (JP) | 2014-04-22 | — | — | US | disclosed |
| US-8703979-B2 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO., LTD. (JP) | 2014-04-22 | — | — | US | disclosed |
| EP-1860103-B1 | ANTICANCER COMPOUND, INTERMEDIATE THEREFOR, AND PROCESSES FOR PRODUCING THESE | TAHEEBO JAPAN CO LTD (JP) | 2012-05-16 | — | — | EP | disclosed |
| EP-1860103-B1 | ANTICANCER COMPOUND, INTERMEDIATE THEREFOR, AND PROCESSES FOR PRODUCING THESE | TAHEEBO JAPAN CO LTD (JP) | 2012-05-16 | — | — | EP | disclosed |
| CN-102432569-A | Novel process for the preparation of tricyclic compounds with anticancer activity via alkyne coupling reactions | TAHEEBO JAPAN CO LTD | 2012-05-02 | — | — | CN | disclosed |
| US-20120077986-A1 | NOVEL PREPARATION OF ANTICANCER-ACTIVE TRICYCLIC COMPOUNDS VIA ALKYNE COUPLING REACTION | TAHEEBO JAPAN CO., LTD. (JP) | 2012-03-29 | — | — | US | disclosed |
| US-20120077986-A1 | NOVEL PREPARATION OF ANTICANCER-ACTIVE TRICYCLIC COMPOUNDS VIA ALKYNE COUPLING REACTION | TAHEEBO JAPAN CO., LTD. (JP) | 2012-03-29 | — | — | US | disclosed |
| US-7910752-B2 | Anticancer compound, intermediate therefor, and processes for producing these | TAHEEBO JAPAN CO., LTD. (JP) | 2011-03-22 | — | — | US | disclosed |
| US-7910752-B2 | Anticancer compound, intermediate therefor, and processes for producing these | TAHEEBO JAPAN CO., LTD. (JP) | 2011-03-22 | — | — | US | disclosed |
| US-7538234-B2 | Preparation of Optically active 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4, 9-diones having anticancer activities | TAHEEBO JAPAN CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20090042977-A1 | Anticancer Compound, Intermediate Therefor, and Processes for Producing These | TAHEEBO JAPAN CO., LTD. (JP) | 2009-02-12 | — | — | US | disclosed |
| US-20090042977-A1 | Anticancer Compound, Intermediate Therefor, and Processes for Producing These | TAHEEBO JAPAN CO., LTD. (JP) | 2009-02-12 | — | — | US | disclosed |
| US-20080300415-A1 | Preparation of optically active 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4, 9-diones having anticancer activities | TAHEEBO JAPAN CO., LTD. (JP) | 2008-12-04 | — | — | US | disclosed |
| CN-101142202-A | Anticancer compound, intermediate therefor, and processes for producing these | TAHEEBO JAPAN KABUSHIKI KAISHA (JP) | 2008-03-12 | — | — | CN | disclosed |
| EP-1860103-A1 | ANTICANCER COMPOUND, INTERMEDIATE THEREFOR, AND PROCESSES FOR PRODUCING THESE | Taheebo Japan Co., Ltd. (JP) | 2007-11-28 | — | — | EP | disclosed |
| EP-1860103-A1 | ANTICANCER COMPOUND, INTERMEDIATE THEREFOR, AND PROCESSES FOR PRODUCING THESE | Taheebo Japan Co., Ltd. (JP) | 2007-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300415-A1 | Preparation of optically active 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4, 9-diones having anticancer activities | DUT, PARP15, NQO1 | MAPT 4825/4885KDM4E 2769/4885RECQL 1213/4885 |
| US-20090042977-A1 | Anticancer Compound, Intermediate Therefor, and Processes for Producing These | NQO1, HADH, HADHB | MAPT 3191/4885KDM4E 2203/4885RECQL 1735/4885 |
| US-20120077986-A1 | NOVEL PREPARATION OF ANTICANCER-ACTIVE TRICYCLIC COMPOUNDS VIA ALKYNE COUPLING REACTION | NR2C2, NR0B2, NR4A2 | MAPT 4425/4885KDM4E 3707/4885RECQL 1367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.