Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.31 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL507789 | 0.77 | GBA1 (0.31) | — | |
| SCHEMBL3387686 | 0.77 | KDM4E (0.36) | KDM4EPOLB | |
| SCHEMBL8546443 | 0.77 | ESR1 (0.32) | — | |
| SCHEMBL8683925 | 0.77 | ESR1 (0.35) | — | |
| SCHEMBL979051 | 0.76 | TYR (0.46) | ALDH1A1ALDH1A3NPSR1 | |
| SCHEMBL8546445 | 0.75 | EGFR (0.30) | — | |
| SCHEMBL6481337 | 0.75 | SMO (0.31) | — | |
| SCHEMBL6475290 | 0.73 | KDM4E (0.36) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL507627 | 0.73 | MAPK1 (0.33) | ALDH1A1 | |
| SCHEMBL5036986 | 0.72 | ALDH1A1 (0.47) | KDM4EALDH1A1L3MBTL1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3162802-B1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | NIHON MEDIPHYSICS CO LTD (JP) | 2020-08-19 | — | — | EP | disclosed |
| CN-106458995-B | 2- (3-pyridyl) -1H-benzimidazole derivative compound and medicine containing the same | 日本医事物理股份有限公司 | 2019-12-20 | — | — | CN | disclosed |
| US-10358434-B2 | 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicament containing same | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2019-07-23 | — | — | US | disclosed |
| US-20190169169-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICAMENT CONTAINING SAME | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2019-06-06 | — | — | US | disclosed |
| US-10189815-B2 | 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicine containing same | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2019-01-29 | — | — | US | disclosed |
| US-20170158668-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2017-06-08 | — | — | US | disclosed |
| EP-3162802-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | Nihon Medi-Physics Co., Ltd. (JP) | 2017-05-03 | — | — | EP | disclosed |
| US-5821255-A | REGULATING THE SECRETION OF CORTICOTROPIN, BETA-ENDORPHIN OR PEPTIDES DERIVED FROM PROOPIOMELANOCORTIN | SANOFI (FR) | 1998-10-13 | — | — | US | disclosed |
| US-5602132-A | USEFUL IN TREATMENT OF PATHOLOGIES INVOLVING CORTICOTROPIN RELEASING FACTOR | SANOFI (FR) | 1997-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169169-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICAMENT CONTAINING SAME | XDH, CYP11B2, GOT2 | KDM4E 2259/4885ALDH1A1 1225/4885L3MBTL1 4465/4885 |
| US-20170158668-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | XDH, REN, BRD4 | KDM4E 1903/4885ALDH1A1 1425/4885L3MBTL1 4265/4885 |
| US-10358434-B2 | 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicament containing same | XDH, CYP11B2, GOT2 | KDM4E 2259/4885ALDH1A1 1225/4885L3MBTL1 4465/4885 |
| US-10189815-B2 | 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicine containing same | XDH, REN, BRD4 | KDM4E 1903/4885ALDH1A1 1425/4885L3MBTL1 4265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.