Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.35 |
| ▸ | BCL2 | P10415 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8684683 | 0.81 | PPARG (0.33) | BCL2MCL1NR1H3 | |
| SCHEMBL8682882 | 0.69 | P4HB (0.43) | BCL2NPC1RAB9AHPGDMCL1 | |
| SCHEMBL6338124 | 0.68 | MGLL (0.55) | NR1H2NPSR1ALDH1A1MAPK1TDP1 | |
| SCHEMBL29754826 | 0.68 | MGLL (0.55) | NR1H2NPSR1ALDH1A1MAPK1TDP1 | |
| SCHEMBL10760113 | 0.67 | ALDH1A1 (0.56) | NPC1RAB9AHPGDKDM4EGAA | |
| SCHEMBL8712071 | 0.66 | MGLL (0.50) | NR1H2GAAMAPTNPSR1ALDH1A1 | |
| SCHEMBL12081658 | 0.65 | MAPT (0.54) | HPGDGAANR1H3MAPTALDH1A1 | |
| SCHEMBL10134069 | 0.65 | MEN1 (0.51) | NPC1RAB9AKDM4EGAAMAPT | |
| SCHEMBL5608665 | 0.63 | MAPT (0.50) | NPC1RAB9AHPGDKDM4EGAA | |
| SCHEMBL29754607 | 0.63 | MGLL (0.65) | NR1H2NPSR1ALDH1A1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5747517-A | ALZHEIMER'S DISEASE; PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-05-05 | — | — | US | disclosed |