Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNA10 | Q9GZZ6 | 2/20 | 0.33 |
| ▸ | CHRNA9 | Q9UGM1 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | YES1 | P07947 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.31 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683882 | 0.78 | LTA4H (0.56) | LTA4HHRH3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8683329 | 0.77 | PSMB1 (0.43) | LTA4HPSMB1PSMB5 | |
| SCHEMBL8417793 | 0.77 | LTA4H (0.68) | LTA4HHRH3PSMB1PSMB5 | |
| SCHEMBL17100113 | 0.75 | LTA4H (0.39) | LTA4HCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL17100252 | 0.74 | GPR88 (0.39) | LTA4HCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL17100236 | 0.68 | LTA4H (0.35) | LTA4HCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8901779 | 0.68 | ESR1 (0.47) | — | |
| SCHEMBL8910200 | 0.68 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL17111330 | 0.68 | TSHR (0.43) | — | |
| SCHEMBL17100290 | 0.68 | PPARA (0.36) | LTA4HCHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731342-A | FOR TREATING AND PREVENTING POSTMENOPAUSAL SYNDROME AND BREAST CANCER | ELI LILLY AND COMPANY (US) | 1998-03-24 | — | — | US | disclosed |