Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688680 | 0.83 | AGTR1 (0.41) | LMNAMAPTKMT2AMAPK1KDM4E | |
| SCHEMBL6937012 | 0.80 | SMN1; SMN2 (0.46) | LMNAMAPTMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL8304940 | 0.76 | HTR6 (0.52) | LMNAMAPTKMT2AMAPK1KDM4E | |
| SCHEMBL8305035 | 0.75 | PPARA (0.51) | LMNAMAPTKMT2AMAPK1KDM4E | |
| SCHEMBL8305033 | 0.75 | PPARA (0.51) | LMNAMAPTKMT2AMAPK1KDM4E | |
| SCHEMBL8686485 | 0.71 | PPARG (0.44) | LMNAMAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL8686175 | 0.70 | CYP1A2 (0.43) | LMNAMAPTMAPK1KDM4EL3MBTL1 | |
| SCHEMBL23635747 | 0.70 | L3MBTL1 (0.57) | LMNAMAPTKMT2AMAPK1L3MBTL1 | |
| SCHEMBL5387372 | 0.70 | MAPT (0.73) | LMNAMAPTKMT2AMAPK1KDM4E | |
| SCHEMBL8686093 | 0.70 | PPARG (0.47) | LMNAMAPTMAPK1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780490-A | A O-(2,4-OXA(OR THIA)ZOLIDINYL)PHENYLOXY(OR THIO OR AMINO) ALKYLOXIME; ALDOSE REDUCTASE INHIBITORS; ANTIDIABETIC AND -HYPOGLYCEMIC AGENTS; LIVER, SKIN AND UROGENITAL DISORDERS | SANKYO COMPANY, LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| US-5703096-A | ANTIDIABETIC AGENTS; ALDOSE REDUCTASE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1997-12-30 | — | — | US | disclosed |