Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrogen Sulfide SCHEMBL28084602 | 0.98 | MAPT (0.71) | MAPTLMNAKMT2AKDM4EMAPK1 | |
| SCHEMBL4027167 | 0.91 | MAPT (0.61) | MAPTLMNAKMT2AKDM4EMAPK1 | |
| SCHEMBL18364472 | 0.88 | KMT2A (0.58) | MAPTLMNAKMT2AKDM4EMAPK1 | |
| SCHEMBL10870974 | 0.86 | HPGD (0.77) | MAPTLMNAKMT2AKDM4EMAPK1 | |
| (Phenylsulfonyl)Benzene SCHEMBL29058880 | 0.84 | HTR6 (0.74) | MAPTLMNAKMT2AKDM4EMAPK1 | |
| (Phenylsulfonyl)Benzene SCHEMBL2381369 | 0.84 | HTR6 (0.74) | MAPTLMNAKMT2AKDM4EMAPK1 | |
| SCHEMBL3773485 | 0.83 | GAA (0.67) | MAPTLMNAKMT2AKDM4EMAPK1 | |
| SCHEMBL7938512 | 0.83 | HSD17B1 (0.63) | MAPTLMNAKMT2AKDM4EMAPK1 | |
| SCHEMBL165237 | 0.83 | HTR6 (0.64) | MAPTLMNAKMT2ACA12CA9 | |
| SCHEMBL24360902 | 0.82 | CA12 (0.70) | MAPTLMNAKMT2AKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650330-B2 | Process for the synthesis of aryl sulfones | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2017-05-16 | — | — | US | claimed |
| US-20160304447-A1 | A PROCESS FOR THE SYNTHESIS OF ARYL SULFONES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-10-20 | — | — | US | claimed |
| WO-2015087352-A1 | A PROCESS FOR THE SYNTHESIS OF ARYL SULFONES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-06-18 | — | — | WO | claimed |
| US-20220204485-A1 | STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS | THE SCRIPPS RESEARCH INSTITUTE | 2022-06-30 | — | — | US | disclosed |
| US-10759765-B2 | Heterocyclic carboxylic acid amide ligand and applications thereof in copper catalyzed coupling reaction of aryl halogeno substitute | CE PHARM CO., LTD. (CN) | 2020-09-01 | — | — | US | disclosed |
| US-20190127337-A1 | HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE | CE PHARM CO., LTD. (CN) | 2019-05-02 | — | — | US | disclosed |
| WO-2017177979-A1 | HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE | 中国科学院上海有机化学研究所 | 2017-10-19 | — | — | WO | disclosed |
| US-9682938-B2 | Pyrazolone derivatives as nitroxyl donors | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-9650330-B2 | Process for the synthesis of aryl sulfones | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2017-05-16 | — | — | US | disclosed |
| US-9650330-B2 | Process for the synthesis of aryl sulfones | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2017-05-16 | — | — | US | disclosed |
| US-9650330-B2 | Process for the synthesis of aryl sulfones | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2017-05-16 | — | — | US | disclosed |
| US-5349090-A | Process for preparing arylketoamines | HOECHST CELANESE CORPORATION (US) | 1994-09-20 | — | — | US | disclosed |
| US-5338884-A | Reacting an arylisonitrosoalkanone with hydrogen then acid, ester inpresence of catalyst | HOECHST CELANESE (US) | 1994-08-16 | — | — | US | disclosed |
| US-5220063-A | Reacting arylisonitrosoalkanone with hydrogen and acyl doner in presence of transition metal catalyst | HOECHST CELANESE CORPORATION (US) | 1993-06-15 | — | — | US | disclosed |
| US-5198585-A | Catalytic hydrogenation of arylisonitrosoalkanone | HOECHST CELANESE CORPORATION (US) | 1993-03-30 | — | — | US | disclosed |
| WO-1993001158-A1 | METHOD FOR THE PREPARATION OF ARYLKETOAMINES | HOECHST CELANESE CORPORATION (US) | 1993-01-21 | — | — | WO | disclosed |
| US-5175368-A | Hydrogenating aryl alpha-oximinoalkyl ketones in aqueous medium containing hydrochlroic acid, recovering salt | HOECHST CELANESE CORPORATION (US) | 1992-12-29 | — | — | US | disclosed |
| EP-0491557-A1 | Process for the preparation of arylalkylamines and substituted arylalkylamines | HOECHST CELANESE CORPORATION (US) | 1992-06-24 | — | — | EP | disclosed |
| US-5041669-A | Reacting alkyl aryl ketones with alkyl nitrites, extracting product, catalytically hydrogenating/reducing in nonaqueous acid mixture | HOECHST CELANESE CORPORATION (US) | 1991-08-20 | — | — | US | disclosed |
| US-4055652-A | 1-[β(R-thio)phenethyl]imidazoles and derivatives thereof | SYNTEX (U.S.A.) INC. (US) | 1977-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220204485-A1 | STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS | TTR, MAP1LC3B, SAAL1 | MAPT 41/4885LMNA 478/4885KMT2A 4134/4885 |
| US-20190127337-A1 | HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE | AOC1, AOC2, AOC3 | MAPT 4463/4885LMNA 4664/4885KMT2A 1850/4885 |
| US-20160304447-A1 | A PROCESS FOR THE SYNTHESIS OF ARYL SULFONES | ARSA, TPST2, STS | MAPT 2353/4885LMNA 4387/4885KMT2A 806/4885 |
| US-10759765-B2 | Heterocyclic carboxylic acid amide ligand and applications thereof in copper catalyzed coupling reaction of aryl halogeno substitute | AOC1, AOC2, AOC3 | MAPT 4463/4885LMNA 4664/4885KMT2A 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.