SCHEMBL8686406

SCHEMBL8686406

Nc1ccncc1Nc1ccccn1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 2/20 0.58
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
GFER P55789 1/20 0.58
ADRA2A P08913 2/20 0.42
ADRA2B P18089 2/20 0.42
ADRA2C P18825 2/20 0.42
EGFR P00533 1/20 0.42
KDR P35968 5/20 0.41
HTT P42858 1/20 0.41
NOD2 Q9HC29 1/20 0.41
NPC1 O15118 2/20 0.41
TP53 P04637 2/20 0.41
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MAPT P10636 2/20 0.41
LMNA P02545 1/20 0.41
NFKB1 P19838 1/20 0.41
MAPK1 P28482 1/20 0.41
NFKB2 Q00653 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16089597 0.86 MAPK10 (0.58) MAPK10MEN1KMT2AGFERADRA2A
SCHEMBL16038144 0.82 MAPK10 (0.41) MAPK10MEN1KMT2AGFEREGFR
SCHEMBL4943709 0.82 MEN1 (0.73) MAPK10MEN1KMT2AGFERADRA2A
SCHEMBL23319534 0.81 MEN1 (0.60) MAPK10MEN1KMT2AGFERADRA2A
SCHEMBL16036495 0.80 ULK1 (0.46) MAPK10EGFRMAPTLMNAHDAC3
SCHEMBL20194777 0.78 MEN1 (0.61) MAPK10MEN1KMT2AGFERADRA2A
SCHEMBL17624578 0.77 MKNK1 (0.41) MAPK10MEN1KMT2AEGFRMAPT
SCHEMBL17624575 0.77 ADRA2A (0.47) MAPK10MEN1KMT2AADRA2AADRA2B
SCHEMBL16067910 0.77 ADRA2A (0.47) MEN1KMT2AADRA2AADRA2BADRA2C
SCHEMBL5779642 0.76 MAPK10 (0.58) MAPK10MEN1KMT2AGFERKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105582900-A Method for preparing polyphenylene sulfide (PPS)-based chelate fiber CHINA PETROLEUM & CHEM CORP 2016-05-18 CN claimed
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 US disclosed
US-11225478-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2022-01-18 US disclosed
CN-110003200-B P2X7 modulators 詹森药业有限公司 2021-11-26 CN disclosed
US-20200325138-A1 P2X7 Modulators JANSSEN PHARMACEUTICA NV (BE) 2020-10-15 US disclosed
US-10703749-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2020-07-07 US disclosed
EP-3495365-A1 P2X7 MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed
US-20190092770-A1 P2X7 Modulators JANSSEN PHARMACEUTICA NV (BE) 2019-03-28 US disclosed
US-20160376271-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV 2016-12-29 US disclosed
US-9464084-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2016-10-11 US disclosed
US-20160039809-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2016-02-11 US disclosed
EP-2970267-A1 P2X7 MODULATORS Janssen Pharmaceutica, N.V. (BE) 2016-01-20 EP disclosed
CN-105209464-A P2x7 modulators JANSSEN PHARMACEUTICA NV 2015-12-30 CN disclosed
US-20150322062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-11-12 US disclosed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US disclosed
WO-2014152604-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 WO disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed
US-5710278-A Herbicidal 1-pyridyltetrazolinones NIHON BAYER AGROCHEM K.K. (JP) 1998-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200325138-A1 P2X7 Modulators P2RX2, P2RX7, P2RY2 MAPK10 1692/4885MEN1 3516/4885KMT2A 4346/4885
US-20160376271-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 MAPK10 1692/4885MEN1 3516/4885KMT2A 4346/4885
US-20190092770-A1 P2X7 Modulators P2RX2, P2RX7, P2RY2 MAPK10 1692/4885MEN1 3516/4885KMT2A 4346/4885
US-11225478-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 MAPK10 1692/4885MEN1 3516/4885KMT2A 4346/4885
US-20160039809-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RX5 MAPK10 1825/4885MEN1 3391/4885KMT2A 4385/4885
US-20150322062-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 MAPK10 1692/4885MEN1 3516/4885KMT2A 4346/4885
US-11820770-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 MAPK10 1692/4885MEN1 3516/4885KMT2A 4346/4885
US-20220213095-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 MAPK10 1692/4885MEN1 3516/4885KMT2A 4346/4885
US-20240116930-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 MAPK10 1692/4885MEN1 3516/4885KMT2A 4346/4885
US-10703749-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 MAPK10 1692/4885MEN1 3516/4885KMT2A 4346/4885
US-20140275015-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 MAPK10 1692/4885MEN1 3516/4885KMT2A 4346/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.