SCHEMBL8686759

SCHEMBL8686759

O=C(O)c1ccncc1F.O=C(O)c1cnccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 1/20 0.47
ROCK1 Q13464 1/20 0.47
KDM4C Q9H3R0 10/20 0.47
KDM6B O15054 5/20 0.47
KDM4D Q6B0I6 4/20 0.47
KDM4E B2RXH2 4/20 0.47
ALDH1A1 P00352 3/20 0.47
KDM4A O75164 2/20 0.47
MEN1 O00255 1/20 0.47
MAPT P10636 1/20 0.47
THRB P10828 1/20 0.47
KMT2A Q03164 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
KDM5A P29375 1/20 0.43
KDM5B Q9UGL1 1/20 0.43
ABL1 P00519 1/20 0.39
ASPH Q12797 2/20 0.39
KDM8 Q8N371 2/20 0.39
KEAP1 Q14145 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29578794 0.88 KDM4C (0.59) KDM4CKDM6BKDM4DKDM4EALDH1A1
SCHEMBL7533 0.88 ROCK2 (0.58) ROCK2ROCK1KDM4CKDM6BKDM4D
SCHEMBL29574646 0.88 ROCK2 (0.58) ROCK2ROCK1KDM4CKDM6BKDM4D
SCHEMBL82604 0.88 KDM4C (0.59) KDM4CKDM6BKDM4DKDM4EALDH1A1
Hydrochloric Acid SCHEMBL17143441 0.86 ROCK2 (0.56) ROCK2ROCK1KDM4CKDM6BKDM4D
Hydrochloric Acid SCHEMBL1942270 0.86 ROCK2 (0.56) ROCK2ROCK1KDM4CKDM6BKDM4D
Hydrochloric Acid SCHEMBL1027857 0.86 KDM4C (0.57) KDM4CKDM6BKDM4DKDM4EALDH1A1
Nitrous Acid SCHEMBL28904582 0.81 KDM4C (0.52) KDM4CKDM6BKDM4DKDM4EALDH1A1
SCHEMBL116912 0.76 KDM4C (0.59) ROCK2ROCK1KDM4CKDM6BKDM4D
SCHEMBL15514423 0.76 ROCK2 (0.58) ROCK2ROCK1KDM4CKDM6BKDM4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5710278-A Herbicidal 1-pyridyltetrazolinones NIHON BAYER AGROCHEM K.K. (JP) 1998-01-20 US disclosed