Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8691529 | 0.86 | ALDH1A1 (0.60) | KMT2AALDH1A1MEN1RAB9AMAPT | |
| SCHEMBL2627998 | 0.86 | KMT2A (0.59) | KMT2AALDH1A1MEN1POLBHCAR2 | |
| SCHEMBL8689529 | 0.85 | HCAR2 (0.59) | TRPA1KMT2AALDH1A1MEN1POLB | |
| SCHEMBL8818748 | 0.85 | ALDH1A1 (0.44) | TRPA1TRPM8KMT2AALDH1A1MEN1 | |
| SCHEMBL8689115 | 0.84 | POLB (0.50) | KMT2AALDH1A1MEN1POLBHCAR2 | |
| SCHEMBL5696412 | 0.83 | DHODH (0.57) | KMT2AALDH1A1MEN1POLBHCAR2 | |
| SCHEMBL8691671 | 0.82 | HDAC1 (0.55) | TRPA1TRPM8KMT2AALDH1A1MEN1 | |
| SCHEMBL8478866 | 0.82 | HDAC1 (0.55) | TRPA1KMT2AALDH1A1MEN1POLB | |
| SCHEMBL8693880 | 0.82 | RAB9A (0.61) | KMT2AALDH1A1MEN1POLBHCAR2 | |
| SCHEMBL8689405 | 0.81 | POLB (0.55) | GRIK1KMT2AALDH1A1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741926-A | ANTIDIABETIC AGENT | SHAMAN PHARMACEUTICALS, INC. (US) | 1998-04-21 | — | — | US | claimed |
| WO-1997030019-A1 | ANILINE DERIVATIVES HAVING ANTIHYPERGLYCEMIC ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-08-21 | — | — | WO | claimed |
| US-5741926-A | ANTIDIABETIC AGENT | SHAMAN PHARMACEUTICALS, INC. (US) | 1998-04-21 | — | — | US | disclosed |
| WO-1997030019-A1 | ANILINE DERIVATIVES HAVING ANTIHYPERGLYCEMIC ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-08-21 | — | — | WO | disclosed |