Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688769 | 0.84 | TRPA1 (0.55) | POLBHCAR2KMT2AMEN1ALDH1A1 | |
| SCHEMBL8688582 | 0.84 | HCAR2 (0.68) | POLBHCAR2KMT2AMEN1KDM4E | |
| SCHEMBL2627998 | 0.83 | KMT2A (0.59) | POLBHCAR2KMT2AMEN1HPGD | |
| SCHEMBL8689529 | 0.82 | HCAR2 (0.59) | POLBHCAR2CYP1A2CYP2C19KMT2A | |
| SCHEMBL5696412 | 0.80 | DHODH (0.57) | POLBDHODHHCAR2KMT2AMEN1 | |
| SCHEMBL8691671 | 0.79 | HDAC1 (0.55) | POLBDHODHKMT2AMEN1HPGD | |
| SCHEMBL8693880 | 0.79 | RAB9A (0.61) | POLBHCAR2KMT2AMEN1HPGD | |
| SCHEMBL8478866 | 0.79 | HDAC1 (0.55) | POLBDHODHCYP1A2CYP2C19KMT2A | |
| SCHEMBL4916093 | 0.76 | KDM4E (0.53) | POLBDHODHHCAR2KMT2AMEN1 | |
| SCHEMBL8691529 | 0.76 | ALDH1A1 (0.60) | CYP1A2CYP2C19KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741926-A | ANTIDIABETIC AGENT | SHAMAN PHARMACEUTICALS, INC. (US) | 1998-04-21 | — | — | US | disclosed |
| WO-1997030019-A1 | ANILINE DERIVATIVES HAVING ANTIHYPERGLYCEMIC ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-08-21 | — | — | WO | disclosed |