SCHEMBL8689529

SCHEMBL8689529

O=C(CNc1ccc(F)cc1)Nc1ccccc1C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 2/20 0.59
KMT2A Q03164 3/20 0.52
ALDH1A1 P00352 3/20 0.52
MAPT P10636 2/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
GAA P10253 1/20 0.52
CYP2C9 P11712 1/20 0.52
HPGD P15428 1/20 0.52
ALOX12 P18054 1/20 0.52
TRPA1 O75762 1/20 0.52
MEN1 O00255 1/20 0.50
LMNA P02545 1/20 0.50
CDC7 O00311 1/20 0.49
DAPK3 O43293 1/20 0.49
PAK4 O96013 1/20 0.49
PIM1 P11309 1/20 0.49
CDK2 P24941 1/20 0.49
FLT3 P36888 1/20 0.49
GSK3B P49841 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2627998 0.90 KMT2A (0.59) HCAR2KMT2AALDH1A1MAPTCYP2C9
SCHEMBL2610130 0.88 ALDH1A1 (0.56) HCAR2ALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL5696412 0.87 DHODH (0.57) HCAR2KMT2AALDH1A1MAPTMEN1
SCHEMBL8693880 0.86 RAB9A (0.61) HCAR2KMT2AALDH1A1MAPTCYP2C9
SCHEMBL8691671 0.86 HDAC1 (0.55) KMT2AALDH1A1MAPTCYP2C9HPGD
SCHEMBL8691560 0.86 ACHE (0.47) HCAR2KMT2AALDH1A1MAPTCYP1A2
SCHEMBL8478866 0.86 HDAC1 (0.55) KMT2AALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL8478651 0.85 HCAR2 (0.56) HCAR2KMT2AALDH1A1MAPTHPGD
SCHEMBL4916093 0.85 KDM4E (0.53) HCAR2KMT2AALDH1A1MAPTMEN1
SCHEMBL8688769 0.85 TRPA1 (0.55) HCAR2KMT2AALDH1A1MAPTTRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5741926-A ANTIDIABETIC AGENT SHAMAN PHARMACEUTICALS, INC. (US) 1998-04-21 US claimed
WO-1997030019-A1 ANILINE DERIVATIVES HAVING ANTIHYPERGLYCEMIC ACTIVITY SHAMAN PHARMACEUTICALS, INC. (US) 1997-08-21 WO claimed
US-5741926-A ANTIDIABETIC AGENT SHAMAN PHARMACEUTICALS, INC. (US) 1998-04-21 US disclosed
WO-1997030019-A1 ANILINE DERIVATIVES HAVING ANTIHYPERGLYCEMIC ACTIVITY SHAMAN PHARMACEUTICALS, INC. (US) 1997-08-21 WO disclosed
US-5217961-A High carcinostatic activity; inhibiting KB-cell growth MECT CORPORATION (JP) 1993-06-08 US disclosed
EP-0376166-A1 Condensed quinoline system compound and process of preparation thereof MECT CORPORATION (JP) 1990-07-04 EP disclosed