Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM5A | P29375 | 3/20 | 0.42 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24127567 | 1.00 | HPGD (0.48) | HPGDHSD11B1MEN1KMT2ANPC1 | |
| SCHEMBL10455923 | 0.88 | KDM5A (0.51) | HPGDHSD11B1NPC1RAB9AKDM5A | |
| SCHEMBL14923343 | 0.82 | MEN1 (0.48) | HPGDHSD11B1MEN1KMT2ANPC1 | |
| SCHEMBL10154212 | 0.81 | ALDH1A1 (0.44) | HPGDHSD11B1MEN1KMT2ANPC1 | |
| SCHEMBL7470707 | 0.80 | ITGB3 (0.41) | ALDH1A1DPP4 | |
| SCHEMBL8496044 | 0.80 | LMNA (0.48) | HPGDHSD11B1MEN1KMT2ANPC1 | |
| SCHEMBL12254583 | 0.79 | GNAI3 (0.45) | HSD11B1NPC1ALDH1A1DPP4 | |
| SCHEMBL25062674 | 0.79 | ALDH1A1 (0.42) | HPGDHSD11B1MEN1KMT2ANPC1 | |
| SCHEMBL6042973 | 0.78 | KMT2A (0.45) | HPGDMEN1KMT2ANPC1RAB9A | |
| SCHEMBL8684586 | 0.78 | KMT2A (0.45) | HPGDMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780473-A | Substituted biphenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-07-14 | — | — | US | disclosed |
| EP-0385686-A2 | Compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |