Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.41 |
| ▸ | F2R | P25116 | 2/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.37 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.37 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070099 | 0.82 | HTR4 (0.40) | ITGB3ITGA2BF2RGNAI3GNAO1 | |
| SCHEMBL9824236 | 0.81 | LMNA (0.45) | ITGB3ITGA2BF2RGNAI3GNAO1 | |
| SCHEMBL9824197 | 0.81 | GNAI3 (0.39) | ITGB3ITGA2BF2RGNAI3GNAO1 | |
| SCHEMBL24127567 | 0.80 | HPGD (0.48) | DPP4ALDH1A1 | |
| SCHEMBL8689463 | 0.80 | HPGD (0.48) | DPP4ALDH1A1 | |
| SCHEMBL9732660 | 0.80 | GABRA5 (0.44) | GNAI3GNAO1GNAI1DPP4SLC6A1 | |
| SCHEMBL1916993 | 0.79 | ITGB3 (0.36) | ITGB3ITGA2BF2RGNAI3GNAO1 | |
| SCHEMBL9734210 | 0.79 | KMT2A (0.52) | DPP4SLC6A1GABRA5GABRB2SLC6A12 | |
| Hydrochloric Acid SCHEMBL27094462 | 0.78 | GABRA5 (0.42) | GNAI3GNAO1GNAI1DPP4SLC6A1 | |
| SCHEMBL3059912 | 0.78 | GNAI3 (0.44) | ITGB3ITGA2BF2RGNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228070-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001029042-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
| US-5147882-A | Cardiovascular disorders | KARL THOMAE GMBH (DE) | 1992-09-15 | — | — | US | disclosed |
| EP-0450429-A1 | Cyclophanes, process for their preparation and pharmaceuticals containing them | Dr. Karl Thomae GmbH (DE) | 1991-10-09 | — | — | EP | disclosed |
| US-4289772-A | PHOSPHODIESTERASE INHIBITORS | PFIZER INC. (US) | 1981-09-15 | — | — | US | disclosed |