Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 10/20 | 0.52 |
| ▸ | HTR2A | P28223 | 8/20 | 0.52 |
| ▸ | DRD2 | P14416 | 7/20 | 0.52 |
| ▸ | HTR1A | P08908 | 6/20 | 0.52 |
| ▸ | HTR6 | P50406 | 5/20 | 0.52 |
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8486561 | 0.99 | HTR7 (0.51) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL8912854 | 0.85 | HTR1A (0.48) | HTR7HTR2ADRD2HTR1AHRH1 | |
| SCHEMBL8684989 | 0.81 | MAPK1 (0.51) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL8486784 | 0.81 | HTR1A (0.61) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL8485571 | 0.77 | DRD2 (0.49) | HTR2ADRD2HTR1ADRD3 | |
| SCHEMBL8716529 | 0.73 | SLC6A4 (0.51) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL5988317 | 0.72 | KCNH2 (0.88) | HTR2ADRD2HTR1AHRH1KCNH2 | |
| SCHEMBL13140376 | 0.71 | KCNH2 (0.69) | HTR7HTR2ADRD2HTR1AHTR6 | |
| Bromide SCHEMBL7207014 | 0.71 | DRD2 (0.67) | HTR7HTR2ADRD2HTR1AHTR6 | |
| SCHEMBL4528457 | 0.70 | KCNH2 (1.00) | HTR7HTR2ADRD2HTR1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998029410-A1 | 1-(N'-(ARYLALKYLAMINOALKYL)) AMINOISOINDOLES; DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-07-09 | — | — | WO | claimed |
| US-5744472-A | NEUROLEPTIC AGENTS | NEUROGEN CORPORATION (US) | 1998-04-28 | — | — | US | claimed |
| WO-1996039403-A1 | 1-(N'-(ARYLALKYLAMINOALKYL)) AMINOISOINDOLES AS DOPAMINE RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1996-12-12 | — | — | WO | claimed |