Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912854 | 0.93 | HTR1A (0.48) | DRD2DRD3LMNAPOLBTSHR | |
| SCHEMBL8485478 | 0.78 | DRD3 (0.58) | DRD2DRD3PIM1HTR1AHTR2A | |
| SCHEMBL8690409 | 0.77 | HTR7 (0.52) | DRD2DRD3HTR1AHTR2A | |
| Bromide SCHEMBL8486561 | 0.76 | HTR7 (0.51) | DRD2DRD3HTR1AHTR2A | |
| SCHEMBL8716529 | 0.74 | SLC6A4 (0.51) | DRD2DRD3POLBDRD4HTR1A | |
| SCHEMBL978209 | 0.74 | DRD2 (0.58) | DRD2DRD3DRD4PIM1HTR1A | |
| SCHEMBL7212266 | 0.73 | HTR1A (0.64) | DRD2DRD3HTTDRD4PIM1 | |
| Bromide SCHEMBL7212285 | 0.72 | HTR1A (0.62) | DRD2DRD3HTTDRD4PIM1 | |
| SCHEMBL8488127 | 0.71 | DRD3 (0.64) | DRD2DRD3HTR1AHTR2AACHE | |
| SCHEMBL8581543 | 0.71 | DRD2 (0.69) | DRD2DRD3DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999021848-A2 | NOVEL 1-(N'-(ARYLALKYLAMINOALKYL))AMINOISOINDOLES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-05-06 | — | — | WO | claimed |
| WO-1998029410-A1 | 1-(N'-(ARYLALKYLAMINOALKYL)) AMINOISOINDOLES; DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-07-09 | — | — | WO | claimed |
| US-5656632-A | 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; dopamine receptor subtype specific ligands | NEUROGEN CORPORATION (US) | 1997-08-12 | — | — | US | claimed |
| WO-1996039403-A1 | 1-(N'-(ARYLALKYLAMINOALKYL)) AMINOISOINDOLES AS DOPAMINE RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1996-12-12 | — | — | WO | claimed |