Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 8/20 | 0.55 |
| ▸ | RARB | P10826 | 7/20 | 0.55 |
| ▸ | RARA | P10276 | 5/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660116 | 0.86 | RARB (0.56) | RARGRARBRARAPDK2RXRA | |
| SCHEMBL8656889 | 0.86 | RARG (0.67) | RARGRARBRARAPDK2RXRA | |
| SCHEMBL8688231 | 0.85 | RARG (0.55) | RARGRARBRARARXRASLC6A4 | |
| SCHEMBL8693295 | 0.80 | RARG (0.50) | RARGRARBRARARXRASLC6A4 | |
| SCHEMBL2884923 | 0.79 | PDK2 (0.57) | PDK2SLC6A4SLC6A3SLC6A2KDM4E | |
| SCHEMBL17327789 | 0.79 | RARB (0.56) | RARGRARBRARARXRASLC6A4 | |
| SCHEMBL8688418 | 0.78 | RARA (0.47) | RARGRARBRARARXRACYP3A4 | |
| SCHEMBL8661405 | 0.77 | RARB (0.54) | RARGRARBRARARXRASLC6A4 | |
| SCHEMBL8690609 | 0.77 | RARA (0.54) | RARGRARBRARASLC6A4SLC6A3 | |
| SCHEMBL6379832 | 0.76 | RARG (0.64) | RARGRARBRARARXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723499-A | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | C.I.R.D. GALDERMA (FR) | 1998-03-03 | — | — | US | disclosed |