SCHEMBL8693286

SCHEMBL8693286

CC[Si](Cl)(Cl)c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 9/20 0.52
TSHR P16473 1/20 0.46
NR1H2 P55055 1/20 0.42
BAX Q07812 1/20 0.42
MAOA P21397 1/20 0.42
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41
PLA2G2A P14555 1/20 0.40
NPC1 O15118 1/20 0.39
HPGD P15428 1/20 0.39
CRHBP P24387 1/20 0.39
RAB9A P51151 1/20 0.39
CRHR2 Q13324 1/20 0.39
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL115193 0.81 TP53 (0.38) TSHRLMNAHPGD
SCHEMBL707866 0.78 ESR1 (0.40) NR1H2
SCHEMBL4733542 0.78 CA1 (0.48) LTA4HLMNANPC1RAB9ACA1
SCHEMBL10319647 0.78 LTA4H (0.52) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL11200862 0.78 KIF11 (0.41) NPC1HPGDRAB9A
SCHEMBL5485054 0.77 LTA4H (0.57) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL10317741 0.76 LTA4H (0.50) LTA4HTSHRNR1H2BAXMAOA
Naphthalene SCHEMBL28055828 0.75 CYP2A6 (0.36) HPGD
SCHEMBL10319919 0.75 LTA4H (0.55) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL6751471 0.74 ALDH1A1 (0.43) TSHRLMNANPC1CRHBPRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5830972-A PHOTOCONDUCTOR SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-11-03 US disclosed