Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.52 |
| ▸ | PTPRA | P18433 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870525 | 0.92 | KMT2A (0.56) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL25357136 | 0.84 | PTPRA (0.53) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL25357144 | 0.84 | PTPRA (0.53) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL18029102 | 0.82 | KMT2A (0.71) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL19871234 | 0.82 | KMT2A (0.71) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL25356584 | 0.78 | PTPRA (0.58) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL25356587 | 0.78 | PTPRA (0.58) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL25361913 | 0.77 | KMT2A (0.57) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL25361906 | 0.77 | KMT2A (0.57) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL18029108 | 0.77 | SCN9A (0.59) | KMT2AMEN1KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009522265-A | — | — | 2009-06-11 | — | — | JP | claimed |
| US-20090054308-A1 | Methods and Compositions for Treating Pulmonary Hypertension and Related Diseases and Disorders | TERSERA THERAPEUTICS LLC | 2009-02-26 | — | — | US | claimed |
| CN-101351451-A | Polycyclic amino acid derivatives and methods of use thereof | LEXICON GENETICS INC (US) | 2009-01-21 | — | — | CN | claimed |
| EP-1984344-A2 | MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-10-29 | — | — | EP | claimed |
| US-20070191370-A1 | Multicyclic amino acid derivatives and methods of their use | TERSERA THERAPEUTICS LLC | 2007-08-16 | — | — | US | claimed |
| WO-2007089335-A2 | MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE | LEXICON PHARMACEUTICAL INC. (US) | 2007-08-09 | — | — | WO | claimed |
| EP-2386547-B1 | Multicyclic amino acid derivatives and methods of their use | LEXICON PHARMACEUTICALS INC (US) | 2018-06-20 | — | — | EP | disclosed |
| US-9717727-B2 | Methods of treating and preventing leukemia and other cancers of the blood and bone | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-01 | — | — | US | disclosed |
| US-9150521-B2 | Methods of preventing and treating diabetes by inhibiting serotonin synthesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-10-06 | — | — | US | disclosed |
| US-20150111908-A1 | METHODS OF DIAGNOSING, PREVENTING, AND TREATING BONE MASS DISEASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-04-23 | — | — | US | disclosed |
| US-20140378489-A1 | METHODS OF PREVENTING AND TREATING DIABETES BY INHIBITING SEROTONIN SYNTHESIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2014-12-25 | — | — | US | disclosed |
| US-20140303197-A1 | METHODS OF TREATING AND PREVENTING LEUKEMIA AND OTHER CANCERS OF THE BLOOD AND BONE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-10-09 | — | — | US | disclosed |
| US-8759364-B2 | Methods of treating bone mass diseases | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-06-24 | — | — | US | disclosed |
| EP-2282756-A1 | METHODS OF DIAGNOSING, PREVENTING AND TREATING BONE MASS DISEASES | The Trustees of Columbia University in the City of New York (US) | 2011-02-16 | — | — | EP | disclosed |
| CN-101969952-A | Compositions comprising tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS INC | 2011-02-09 | — | — | CN | disclosed |
| CN-101815534-A | methods and compositions for treating pulmonary hypertension and related diseases and disorders | LEXICON PHARMACEUTICALS INC | 2010-08-25 | — | — | CN | disclosed |
| CN-101801385-A | Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein | LEXICON PHARMACEUTICALS INC | 2010-08-11 | — | — | CN | disclosed |
| CN-101784269-A | methods of treating serotonin-mediated diseases and disorders | LEXICON PHARMACEUTICALS INC | 2010-07-21 | — | — | CN | disclosed |
| WO-2009123978-A1 | METHODS OF DIAGNOSING, PREVENTING AND TREATING BONE MASS DISEASES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-10-08 | — | — | WO | disclosed |
| CN-101351451-A | Polycyclic amino acid derivatives and methods of use thereof | LEXICON GENETICS INC (US) | 2009-01-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111908-A1 | METHODS OF DIAGNOSING, PREVENTING, AND TREATING BONE MASS DISEASES | TPH1, HTR1A, TPH2 | KMT2A 1208/4885MEN1 383/4885KDM4E 1709/4885 |
| US-20090054308-A1 | Methods and Compositions for Treating Pulmonary Hypertension and Related Diseases and Disorders | TPH1, PAH, TPH2 | KMT2A 2842/4885MEN1 2455/4885KDM4E 3310/4885 |
| US-20140378489-A1 | METHODS OF PREVENTING AND TREATING DIABETES BY INHIBITING SEROTONIN SYNTHESIS | TPH1, TPH2, HTR1A | KMT2A 1349/4885MEN1 651/4885KDM4E 1361/4885 |
| US-20070191370-A1 | Multicyclic amino acid derivatives and methods of their use | AADAT, HNMT, TPH1 | KMT2A 2950/4885MEN1 1261/4885KDM4E 4376/4885 |
| US-20140303197-A1 | METHODS OF TREATING AND PREVENTING LEUKEMIA AND OTHER CANCERS OF THE BLOOD AND BONE | TPH1, TPH2, HNMT | KMT2A 474/4885MEN1 161/4885KDM4E 1491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.