Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8696856 | 0.94 | ALDH1A1 (0.40) | KMT2AAGTR1HTTALDH1A1GAA | |
| SCHEMBL8696818 | 0.90 | HTT (0.41) | KMT2ATEAD2AGTR1HTTALDH1A1 | |
| SCHEMBL8693996 | 0.87 | AGTR1 (0.47) | KMT2AAGTR1HTTALDH1A1NPC1 | |
| SCHEMBL8694568 | 0.84 | TEAD2 (0.39) | KMT2ATEAD2ALDH1A1GAAHPGD | |
| SCHEMBL8692506 | 0.84 | TEAD2 (0.39) | KMT2ATEAD2ALDH1A1GAAHPGD | |
| SCHEMBL8698709 | 0.84 | ALDH1A1 (0.53) | KMT2AHTTALDH1A1GAAHPGD | |
| SCHEMBL8696097 | 0.83 | HTT (0.42) | KMT2AAGTR1HTTALDH1A1NPC1 | |
| SCHEMBL8693075 | 0.81 | NPC1 (0.47) | KMT2ATEAD2HTTALDH1A1GAA | |
| SCHEMBL8696980 | 0.80 | TEAD2 (0.37) | KMT2ATEAD2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL8698769 | 0.79 | ALDH1A1 (0.45) | AGTR1ALDH1A1NPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849779-A | Pyrazole derivatives and their pharmaceutical use | JAPAN ENERGY CORPORATION (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0810217-A1 | Pyrazole derivatives and their pharmaceutical use as smooth muscle cell growth inhibitors | JAPAN ENERGY CORPORATION (JP) | 1997-12-03 | — | — | EP | disclosed |