Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8699518 | 0.79 | ALDH1A1 (0.44) | NPC1RAB9APOLBSMN1; SMN2MAPT | |
| SCHEMBL8701009 | 0.76 | ALOX5 (0.46) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL101223 | 0.76 | HDAC1 (0.51) | NPC1RAB9APOLBTRPV1SMN1; SMN2 | |
| SCHEMBL8701679 | 0.75 | HDAC1 (0.57) | NPC1RAB9ATRPV1SMN1; SMN2MAPT | |
| SCHEMBL99412 | 0.74 | HCAR2 (0.47) | NPC1RAB9APOLBTRPV1SMN1; SMN2 | |
| SCHEMBL101227 | 0.73 | NPC1 (0.45) | NPC1RAB9APOLBTRPV1SMN1; SMN2 | |
| SCHEMBL99703 | 0.73 | NPC1 (0.58) | NPC1RAB9APOLBTRPV1SMN1; SMN2 | |
| SCHEMBL19501635 | 0.73 | TRPV1 (0.77) | NPC1RAB9APOLBTRPV1SMN1; SMN2 | |
| SCHEMBL101623 | 0.73 | HDAC2 (0.48) | TRPV1SMN1; SMN2MAPTALDH1A1HDAC1 | |
| SCHEMBL15822177 | 0.73 | HDAC1 (0.47) | NPC1RAB9APOLBTRPV1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726319-A | Biphenyl substituted dipeptide analogs promote release of growth hormone | MERCK & CO., INC. (US) | 1998-03-10 | — | — | US | disclosed |