Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 10/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8697083 | 1.00 | TRPV1 (0.45) | TRPV1PTPN11KCNH2 | |
| SCHEMBL7395300 | 0.88 | PTPN11 (0.48) | PTPN11KCNH2 | |
| Fumaric Acid SCHEMBL8699041 | 0.81 | PTPN11 (0.47) | PTPN11 | |
| Maleic Acid SCHEMBL8699032 | 0.81 | PTPN11 (0.47) | PTPN11 | |
| SCHEMBL20361410 | 0.77 | TRPV1 (0.46) | TRPV1 | |
| Fumaric Acid SCHEMBL8696754 | 0.77 | KDM4E (0.46) | PTPN11KCNH2 | |
| Maleic Acid SCHEMBL8696748 | 0.77 | KDM4E (0.46) | PTPN11KCNH2 | |
| SCHEMBL7390806 | 0.75 | TRPV1 (0.49) | TRPV1 | |
| SCHEMBL15260026 | 0.72 | TRPV1 (0.44) | TRPV1KCNH2 | |
| SCHEMBL4815499 | 0.72 | TRPV1 (0.64) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5595994-A | 1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1997-01-21 | — | — | US | claimed |
| US-5723611-A | Heteroarylpiperidines | SANOFI (FR) | 1998-03-03 | — | — | US | disclosed |
| US-5595994-A | 1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1997-01-21 | — | — | US | disclosed |
| US-5502063-A | 1-halopyridin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |