Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.64 |
| ▸ | MMP1 | P03956 | 12/20 | 0.64 |
| ▸ | MMP9 | P14780 | 11/20 | 0.64 |
| ▸ | MMP8 | P22894 | 8/20 | 0.64 |
| ▸ | MMP3 | P08254 | 3/20 | 0.64 |
| ▸ | MMP14 | P50281 | 2/20 | 0.64 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.64 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.64 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.64 |
| ▸ | MMP7 | P09237 | 1/20 | 0.64 |
| ▸ | MMP12 | P39900 | 1/20 | 0.64 |
| ▸ | MMP13 | P45452 | 1/20 | 0.64 |
| ▸ | MMP15 | P51511 | 1/20 | 0.64 |
| ▸ | MMP16 | P51512 | 1/20 | 0.64 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.64 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.64 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.64 |
| ▸ | MMP17 | Q9ULZ9 | 1/20 | 0.64 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6413828 | 0.87 | MMP2 (0.68) | MMP2MMP1MMP9MMP8MMP3 | |
| SCHEMBL24171263 | 0.85 | MMP1 (0.61) | MMP2MMP1MMP9MMP8MMP3 | |
| SCHEMBL8014479 | 0.84 | MMP1 (0.67) | MMP2MMP1MMP9MMP8MMP3 | |
| SCHEMBL16298104 | 0.84 | MMP2 (0.64) | MMP2MMP1MMP9MMP8MMP3 | |
| SCHEMBL8019394 | 0.81 | MMP1 (0.59) | MMP2MMP1MMP9MMP8MMP3 | |
| SCHEMBL24170939 | 0.81 | MMP2 (0.68) | MMP2MMP1MMP9MMP8MMP3 | |
| SCHEMBL24171253 | 0.81 | MMP2 (0.68) | MMP2MMP1MMP9MMP8MMP3 | |
| SCHEMBL25139559 | 0.81 | MMP9 (0.76) | MMP2MMP1MMP9MMP8MMP3 | |
| SCHEMBL24171242 | 0.80 | MMP2 (0.65) | MMP2MMP1MMP9MMP8MMP3 | |
| SCHEMBL641549 | 0.80 | CCKBR (0.70) | MMP2MMP1MMP9MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5853623-A | Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases | CHIROSCIENCE LIMITED (GB) | 1998-12-29 | — | — | US | disclosed |
| EP-0728144-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | Chiroscience Limited (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013289-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | CHIROSCIENCE LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |