Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8698524 | 0.88 | FLT1 (0.33) | CYP11B1CYP11B2FLT1FLT4KDR | |
| SCHEMBL8697941 | 0.88 | CYP11B1 (0.34) | CYP11B1CYP11B2FLT1FLT4KDR | |
| SCHEMBL8698118 | 0.85 | CYP11B1 (0.33) | CYP11B1CYP11B2 | |
| SCHEMBL8697482 | 0.81 | CYP19A1 (0.33) | CYP11B1CYP11B2KDM4EALDH1A1MAPT | |
| SCHEMBL8698099 | 0.73 | KCNA5 (0.36) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL8698606 | 0.73 | ATM (0.32) | — | |
| SCHEMBL8704175 | 0.69 | CYP2A6 (0.34) | CYP11B1CYP11B2MAPT | |
| SCHEMBL8700262 | 0.67 | CYP19A1 (0.42) | CYP11B1CYP11B2FLT1FLT4KDR | |
| SCHEMBL8702189 | 0.63 | ATM (0.36) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11136545 | 0.62 | ATM (0.44) | CYP11B1CYP11B2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | claimed |
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | disclosed |