SCHEMBL8698135

SCHEMBL8698135

Cc1nc2[nH]c(=O)nc(N)c2nc1[C@H]1C[C@H](O)[C@@H](CO)O1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 3/20 0.35
LMNA P02545 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
ADRB1 P08588 1/20 0.35
PNP P00491 1/20 0.34
TP53 P04637 1/20 0.34
HTT P42858 1/20 0.34
PDE4D Q08499 1/20 0.34
PDE3A Q14432 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34
OGA O60502 1/20 0.33
GALR3 O60755 1/20 0.32
NR2F2 P24468 1/20 0.32
TK1 P04183 2/20 0.31
TK2 O00142 1/20 0.31
ADORA3 P0DMS8 1/20 0.30
ADORA2A P29274 1/20 0.30
POLA1 P09884 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8961007 0.96 DNMT1 (0.35) DNMT1LMNASMN1; SMN2ADRB1PNP
SCHEMBL8927785 0.78 DNMT1 (0.39) DNMT1LMNASMN1; SMN2ADRB1PNP
SCHEMBL8927834 0.77 LMNA (0.38) DNMT1LMNASMN1; SMN2ADRB1OGA
SCHEMBL7661689 0.72 LMNA (0.38) DNMT1LMNASMN1; SMN2ADRB1PNP
SCHEMBL18190788 0.72 DNMT1 (0.39) DNMT1LMNASMN1; SMN2ADRB1PNP
SCHEMBL9633782 0.71 LMNA (0.37) DNMT1LMNASMN1; SMN2ADRB1OGA
SCHEMBL9634749 0.71 LMNA (0.37) DNMT1LMNASMN1; SMN2ADRB1OGA
SCHEMBL16631956 0.66 TK1 (0.37) DNMT1LMNASMN1; SMN2ADRB1TK1
SCHEMBL9751247 0.65 ADRB1 (0.38) DNMT1LMNASMN1; SMN2ADRB1OGA
SCHEMBL8663124 0.65 ADRB1 (0.38) DNMT1LMNASMN1; SMN2ADRB1OGA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998026093-A2 FLUORESCENT NUCLEOTIDE ANALOG HAIRPIN FORMATION FOR DETECTION OF NUCLEIC ACID HYBRIDIZATION THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-06-18 WO claimed