SCHEMBL8703296

SCHEMBL8703296

Cc1c(Cl)c(O)nc2ccc(N)cc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.44
KDM4E B2RXH2 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41
HSD17B10 Q99714 1/20 0.41
ACHE P22303 2/20 0.40
LMNA P02545 1/20 0.40
POLB P06746 1/20 0.40
CASP6 P55212 1/20 0.40
NQO2 P16083 2/20 0.39
MPO P05164 1/20 0.37
CYP3A4 P08684 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
TSHR P16473 1/20 0.36
CASP1 P29466 1/20 0.36
PDE10A Q9Y233 1/20 0.36
CTDSP1 Q9GZU7 1/20 0.36
PDE4D Q08499 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8703074 0.80 EPRS1 (0.40) MAPTKDM4ESMN1; SMN2ALDH1A1HPGD
SCHEMBL11592944 0.74 KDM4E (0.43) MAPTKDM4ESMN1; SMN2ALDH1A1HPGD
SCHEMBL3390039 0.74 NQO2 (0.53) KDM4ESMN1; SMN2ALDH1A1HSD17B10ACHE
SCHEMBL27931468 0.73 KDM4E (0.46) MAPTKDM4ESMN1; SMN2ALDH1A1HPGD
SCHEMBL8707994 0.71 MAOA (0.31) MAPT
SCHEMBL9861710 0.70 LMNA (0.43) MAPTKDM4ESMN1; SMN2ALDH1A1HPGD
SCHEMBL5349570 0.70 TSHR (0.44) MAPTKDM4ESMN1; SMN2ALDH1A1HPGD
SCHEMBL5910832 0.70 KDM4E (0.62) MAPTKDM4ESMN1; SMN2ALDH1A1HPGD
SCHEMBL19680535 0.70 MAPT (0.44) MAPTKDM4ESMN1; SMN2ALDH1A1HPGD
SCHEMBL7496154 0.69 CTDSP1 (0.41) MAPTKDM4ESMN1; SMN2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5770709-A BRILLIANT COLOR SHADES, GOOD FASTNESS DURING USE AT HIGH DEGREE OF FIXING DYSTAR TEXTILFARBEN GMBH & CO DEUTSCHLAND KG (DE) 1998-06-23 US disclosed