Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.46 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.46 |
| ▸ | HTR1D | P28221 | 15/20 | 0.46 |
| ▸ | HTR1B | P28222 | 13/20 | 0.46 |
| ▸ | HTR1F | P30939 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8708476 | 1.00 | HTR1D (0.46) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8709412 | 0.94 | SLC6A4 (0.52) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8713578 | 0.89 | SLC6A4 (0.52) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| Fumaric Acid SCHEMBL8382079 | 0.86 | HTR1D (0.41) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8708176 | 0.86 | HTR1D (0.53) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8387192 | 0.84 | HTR1D (0.57) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8383499 | 0.83 | SLC6A4 (0.51) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| Hydrochloric Acid SCHEMBL8386523 | 0.83 | HTR1D (0.56) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8724293 | 0.82 | HTR6 (0.49) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8383598 | 0.82 | SLC6A4 (0.47) | HTR1DHTR1BHTR1AHTR1FSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998046570-A1 | SUBSTITUTED HETEROAROMATIC 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-10-22 | — | — | WO | disclosed |