Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GRK6 | P43250 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713676 | 0.88 | GAA (0.45) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL8712627 | 0.78 | GAA (0.35) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL8709911 | 0.77 | ALOX5 (0.44) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL12892200 | 0.72 | MPO (0.57) | ALDH1A1GAAGRK6MAPTSMN1; SMN2 | |
| SCHEMBL8710518 | 0.72 | MAPT (0.45) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL8043845 | 0.72 | HSD17B10 (0.45) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL7462417 | 0.69 | CFD (0.44) | KDM4EALDH1A1HPGDHSD17B10GRK6 | |
| SCHEMBL8714020 | 0.69 | MAPT (0.51) | ALDH1A1GAAMAPTLMNASMN1; SMN2 | |
| SCHEMBL187940 | 0.67 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL10029581 | 0.67 | KDM4E (0.81) | KDM4EALDH1A1HPGDGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |