SCHEMBL8710959

SCHEMBL8710959

C=C(c1ccccc1)P(=O)(Cl)Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.42
CA4 P22748 2/20 0.42
CA5A P35218 2/20 0.42
CES1 P23141 4/20 0.40
CES2 O00748 3/20 0.40
ALDH1A1 P00352 2/20 0.40
TSHR P16473 2/20 0.40
DAO P14920 1/20 0.40
NAPRT Q6XQN6 1/20 0.40
CA12 O43570 2/20 0.39
CA1 P00915 2/20 0.39
CA9 Q16790 2/20 0.39
HSD17B10 Q99714 2/20 0.39
ALOX15 P16050 2/20 0.39
HDAC3 O15379 1/20 0.39
IDO1 P14902 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC8 Q9BY41 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21352327 0.78 CA2 (0.44) CA2CA4CA5ACES1CES2
SCHEMBL95085 0.78 L3MBTL1 (0.48) CA2CA4CA5ACES1CES2
SCHEMBL14681161 0.76 TSHR (0.42) CES1CES2ALDH1A1TSHRDAO
Lithium Ion SCHEMBL23405474 0.76 CA2 (0.41) CA2CA4CA5ACES1CES2
SCHEMBL23405501 0.76 CA2 (0.46) CA2CA4CA5ACES1CES2
Potassium Ion SCHEMBL23405488 0.76 CA2 (0.41) CA2CA4CA5ACES1CES2
SCHEMBL10040040 0.74 TSHR (0.41) CA2CA4CA5ACES1CES2
SCHEMBL30266166 0.74 CA2 (0.46) CA2CA4CA5ACES1CES2
SCHEMBL28505427 0.73 ALDH1A1 (0.55) CA2CA4CA5ACES1CES2
SCHEMBL21352361 0.73 ALDH1A1 (0.48) CA2CA4CA5ACES1CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5728756-A BETA-STYRENEPHOSPHONIC ACID-VINYL PHOSPHONIC ACID COPOLYMER FOR ANTIPLAQUE COLGATE PALMOLIVE COMPANY (US) 1998-03-17 US disclosed
US-5538715-A DENTIFRICES WITH ANTIPLAQUE AGENTS FOR MOUTHS WITH HUMECTANTS, SILICA POLISHES AND BACTERICIDES COLGATE PALMOLIVE COMPANY (US) 1996-07-23 US disclosed
US-5344641-A Antibacterial antiplaque oral composition COLGATE-PALMOLIVE CO. (US) 1994-09-06 US disclosed
US-5192530-A Solubilizer, enhancing agent to aid retention, and delivery enhancement COLGATE-PALMOLIVE COMPANY (US) 1993-03-09 US disclosed