Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14681161 | 0.84 | TSHR (0.42) | TSHRLMNAMAPTXBP1ATM | |
| SCHEMBL95085 | 0.81 | L3MBTL1 (0.48) | TSHRCA2CA4CA5ALMNA | |
| SCHEMBL21352327 | 0.81 | CA2 (0.44) | TSHRCA2CA4CA5ALMNA | |
| SCHEMBL14198464 | 0.78 | ESR1 (0.45) | TSHRCA2CA4CA5ALMNA | |
| SCHEMBL2322359 | 0.77 | ALDH1A1 (0.40) | TSHRCA2CA4CA5ALMNA | |
| SCHEMBL2318394 | 0.77 | LMNA (0.46) | TSHRCA2CA4CA5ALMNA | |
| SCHEMBL9300577 | 0.77 | LMNA (0.46) | TSHRCA2CA4CA5ALMNA | |
| Lithium Ion SCHEMBL23405474 | 0.74 | CA2 (0.41) | TSHRCA2CA4CA5ALMNA | |
| Potassium Ion SCHEMBL23405488 | 0.74 | CA2 (0.41) | TSHRCA2CA4CA5ALMNA | |
| SCHEMBL23405501 | 0.74 | CA2 (0.46) | TSHRCA2CA4CA5ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9198923-B2 | Phosphate management with small molecules | Opko Ireland Global Holdings, Ltd. (KY) | 2015-12-01 | — | — | US | disclosed |
| US-20120028926-A1 | Phosphate Management with Small Molecules | CYTOCHROMA INC. (CA) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028926-A1 | Phosphate Management with Small Molecules | SLC34A2, PHPT1, SLC34A3 | TSHR 2366/4885CA2 94/4885CA4 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.