Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.78 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | RAD52 | P43351 | 1/20 | 0.67 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458136 | 0.87 | POLB (1.00) | POLBHTTRAD52LIMK2KMT2A | |
| SCHEMBL3380247 | 0.86 | POLB (0.68) | POLBHTTKMT2AMEN1GAA | |
| SCHEMBL2897956 | 0.84 | CCR1 (0.60) | POLBL3MBTL1SLC16A3 | |
| SCHEMBL3144642 | 0.84 | CCR2 (0.62) | POLBRAD52ALDH1A1 | |
| SCHEMBL3562888 | 0.83 | SLC16A3 (0.64) | POLBHTTLIMK2SMN1; SMN2L3MBTL1 | |
| SCHEMBL25073147 | 0.83 | ACLY (0.66) | POLBRAD52LIMK2KMT2AALDH1A1 | |
| SCHEMBL5459200 | 0.82 | ALDH1A1 (0.66) | POLBHTTLIMK2KMT2AMEN1 | |
| SCHEMBL7572319 | 0.82 | POLB (0.68) | POLBHTTKMT2AMEN1GAA | |
| SCHEMBL7571620 | 0.82 | POLB (0.68) | POLBHTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL789616 | 0.82 | KEAP1 (0.72) | POLBHTTKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |