Water

Water

SCHEMBL8711848

O.O=S(=O)(c1ccccc1O)c1ccccc1O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR known ✓ P00533 1/20 0.45
PIK3CA known ✓ P42336 1/20 0.45
ABCC9 known ✓ O60706 1/20 0.41
KCNJ11 known ✓ Q14654 1/20 0.41
MEN1 known ✓ O00255 2/20 0.41
HTR6 known ✓ P50406 1/20 0.38
TDP1 Q9NUW8 4/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
ALPL P05186 1/20 0.48
ALPI P09923 1/20 0.48
ALPG P10696 1/20 0.48
DNMT1 P26358 1/20 0.48
MCL1 Q07820 1/20 0.48
GAA P10253 2/20 0.48
POLB P06746 2/20 0.45
GFER P55789 1/20 0.45
CA2 P00918 3/20 0.45
CA4 P22748 3/20 0.45
CA12 O43570 2/20 0.45
CA5A P35218 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29381412 0.97 TDP1 (0.50) TDP1L3MBTL1ALPLALPIALPG
SCHEMBL18837 0.97 TDP1 (0.50) TDP1L3MBTL1ALPLALPIALPG
SCHEMBL190005 0.97 TDP1 (0.50) TDP1L3MBTL1ALPLALPIALPG
Fluoride SCHEMBL28328013 0.95 TDP1 (0.48) TDP1L3MBTL1ALPLALPIALPG
SCHEMBL8652280 0.95 GAA (0.50) TDP1L3MBTL1ALPLALPIALPG
SCHEMBL8652278 0.95 TDP1 (0.48) TDP1L3MBTL1ALPLALPIALPG
Formaldehyde SCHEMBL7206155 0.92 TDP1 (0.47) TDP1L3MBTL1ALPLALPIALPG
Benzene SCHEMBL28329054 0.92 GAA (0.48) TDP1L3MBTL1ALPLALPIALPG
Phenol SCHEMBL27474455 0.88 CA12 (0.50) TDP1L3MBTL1ALPLALPIALPG
SCHEMBL6241059 0.86 TDP1 (0.43) TDP1L3MBTL1ALPLALPIALPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882149-A1 CARBOXYLIC ACID-CONTAINING POLYMER/RESOLE RESIN STAIN-RESISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-12-09 EP claimed
US-5708087-A Carboxylic acid-containing polymer/resole stain-resists E. I. DU PONT DE NEMOURS AND COMPANY (US) 1998-01-13 US claimed
WO-1997031149-A1 CARBOXYLIC ACID-CONTAINING POLYMER/RESOLE RESIN STAIN-RESISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-08-28 WO claimed