Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Propamidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.81 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.81 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.81 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.81 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.92 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.89 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.81 |
| ▸ | F2 | P00734 | 2/20 | 0.81 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.81 |
| ▸ | PLAU | P00749 | 1/20 | 0.81 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.81 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.81 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.81 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.81 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.81 |
| ▸ | F10 | P00742 | 1/20 | 0.81 |
| ▸ | PLG | P00747 | 1/20 | 0.81 |
| ▸ | S100B | P04271 | 1/20 | 0.81 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.81 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propamidine SCHEMBL231060 | 0.96 | TMPRSS2 (1.00) | TMPRSS2PRSS1PRMT1F2ST14 | |
| Propamidine SCHEMBL2689252 | 0.94 | PRSS1 (1.00) | TMPRSS2PRSS1PRMT1F2ST14 | |
| Hexamidine SCHEMBL28086219 | 0.92 | PRMT1 (0.96) | TMPRSS2PRSS1PRMT1F2ST14 | |
| SCHEMBL6408670 | 0.92 | PRSS1 (1.00) | TMPRSS2PRSS1PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL28283096 | 0.91 | PRSS1 (0.76) | TMPRSS2PRSS1PRMT1F2ST14 | |
| Pentamidine SCHEMBL3329 | 0.90 | PRMT1 (1.00) | TMPRSS2PRSS1PRMT1F2ST14 | |
| Heptamidine SCHEMBL14599630 | 0.90 | PRMT1 (1.00) | TMPRSS2PRSS1PRMT1F2ST14 | |
| Hexamidine SCHEMBL144738 | 0.90 | PRMT1 (1.00) | TMPRSS2PRSS1PRMT1F2ST14 | |
| SCHEMBL14599628 | 0.90 | PRMT1 (1.00) | TMPRSS2PRSS1PRMT1F2ST14 | |
| SCHEMBL14599639 | 0.90 | PRMT1 (1.00) | TMPRSS2PRSS1PRMT1F2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 559 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010893-B1 | ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2019-10-02 | — | — | EP | claimed |
| EP-3395171-A1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYLSULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | Bayer CropScience Aktiengesellschaft (DE) | 2018-10-31 | — | — | EP | claimed |
| EP-3010889-B1 | ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2018-10-03 | — | — | EP | claimed |
| EP-2793578-B1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYLSULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2018-06-06 | — | — | EP | claimed |
| US-9642363-B2 | N-arylamidine-substituted trifluoroethyl sulfide derivatives as acaricides and insecticides | BAYER CROPSCIENCE AG (DE) | 2017-05-09 | — | — | US | claimed |
| CN-105722830-A | Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides | 拜耳作物科学股份公司 | 2016-06-29 | — | — | CN | claimed |
| US-20160145235-A1 | ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-05-26 | — | — | US | claimed |
| US-20160130240-A1 | ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-05-12 | — | — | US | claimed |
| EP-3010893-A1 | ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | Bayer CropScience Aktiengesellschaft (DE) | 2016-04-27 | — | — | EP | claimed |
| EP-3010889-A1 | ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | Bayer CropScience Aktiengesellschaft (DE) | 2016-04-27 | — | — | EP | claimed |
| WO-2014037315-A2 | ACTIVE COMPOUND COMBINATIONS | BAYER CROPSCIENCE AG (DE) | 2014-03-13 | — | — | WO | claimed |
| CN-103635089-A | Active compound combinations comprising a (thio)carboxamide derivative and a fungicidal compound | BAYER IP GMBH | 2014-03-12 | — | — | CN | claimed |
| EP-2699093-A1 | ACTIVE COMPOUND COMBINATIONS COMPRISING A (THIO)CARBOXAMIDE DERIVATIVE AND A FUNGICIDAL COMPOUND | Bayer Intellectual Property GmbH (DE) | 2014-02-26 | — | — | EP | claimed |
| US-20140038823-A1 | ACTIVE COMPOUND COMBINATIONS COMPRISING A (THIO)CARBOXAMIDE DERIVATIVE AND A FUNGIDICAL COMPOUND | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2014-02-06 | — | — | US | claimed |
| WO-2013092350-A1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2013-06-27 | — | — | WO | claimed |
| EP-2606726-A1 | N-Arylamidine-substituted trifluoroethylsulfide derivatives as acaricides and insecticides | Bayer CropScience AG (DE) | 2013-06-26 | — | — | EP | claimed |
| EP-2515649-A2 | ACTIVE COMPOUND COMBINATIONS | Bayer Intellectual Property GmbH (DE) | 2012-10-31 | — | — | EP | claimed |
| WO-2012143127-A1 | ACTIVE COMPOUND COMBINATIONS COMPRISING A (THIO)CARBOXAMIDE DERIVATIVE AND A FUNGICIDAL COMPOUND | BAYER CROPSCIENCES AG (DE) | 2012-10-26 | — | — | WO | claimed |
| EP-2398326-A1 | PESTICIDE COMPOSITION COMPRISING A TETRAZOLYLOXIME DERIVATIVE AND A FUNGICIDE OR AN INSECTICIDE ACTIVE SUBSTANCE | Bayer CropScience AG (DE) | 2011-12-28 | — | — | EP | claimed |
| WO-2010094728-A1 | PESTICIDE COMPOSITION COMPRISING A TETRAZOLYLOXIME DERIVATIVE AND A FUNGICIDE OR AN INSECTICIDE ACTIVE SUBSTANCE | BAYER CROPSCIENCE AG (DE) | 2010-08-26 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130240-A1 | ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | ARSA, SQOR, AHR | CHRM2 2435/4885ACHE 140/4885SLC6A2 3510/4885 |
| US-20160145235-A1 | ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | ARSA, SQOR, AHR | CHRM2 2872/4885ACHE 149/4885SLC6A2 3135/4885 |
| US-20140038823-A1 | ACTIVE COMPOUND COMBINATIONS COMPRISING A (THIO)CARBOXAMIDE DERIVATIVE AND A FUNGIDICAL COMPOUND | AADAC, TUBA3C, NAT1 | CHRM2 3463/4885ACHE 1497/4885SLC6A2 4589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.