Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 4/20 | 0.33 |
| ▸ | SKP1 | P63208 | 4/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713210 | 0.93 | CKS1B (0.38) | CNR2HTR1ADRD2DRD4MDM2 | |
| SCHEMBL7863439 | 0.79 | DRD2 (0.34) | CNR2HTR1ADRD2DRD4TP53 | |
| SCHEMBL7872441 | 0.79 | DRD2 (0.33) | CNR2HTR1ADRD2DRD4TP53 | |
| Hydrochloric Acid SCHEMBL8718961 | 0.77 | ADORA3 (0.37) | KCNH2GRM2ADORA3ADORA2APDE5A | |
| SCHEMBL7871653 | 0.76 | PDE5A (0.37) | CNR2TP53KCNH2GRM2ADORA3 | |
| SCHEMBL7872489 | 0.76 | DRD2 (0.38) | CNR2DRD2ADORA3ADORA2APDE5A | |
| Hydrochloric Acid SCHEMBL7872363 | 0.76 | PDE5A (0.36) | CNR2TP53KCNH2GRM2ADORA3 | |
| SCHEMBL8713886 | 0.75 | HTR1A (0.34) | HTR1ADRD2DRD4KCNH2 | |
| SCHEMBL8713955 | 0.75 | ALDH1A1 (0.45) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7868708 | 0.75 | GPR119 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826686-A2 | Tricyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-04 | — | — | EP | disclosed |