Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712738 | 0.85 | KDM4C (0.40) | MEN1KMT2ALMNAHPGDTMPRSS4 | |
| SCHEMBL27440948 | 0.84 | HPGD (0.51) | MEN1KMT2ALMNAHTTHPGD | |
| SCHEMBL27411540 | 0.81 | PDK1 (0.41) | GRM5 | |
| SCHEMBL27796034 | 0.79 | MEN1 (0.56) | MEN1KMT2ALMNAKCNMA1HTT | |
| SCHEMBL8712344 | 0.79 | GRM4 (0.41) | MEN1KMT2ALMNAHTTHPGD | |
| SCHEMBL8710268 | 0.79 | XDH (0.43) | MEN1KMT2AGRM5MAPT | |
| SCHEMBL8772947 | 0.78 | KCNMA1 (0.48) | KMT2ALMNAKCNMA1HPGDGAA | |
| SCHEMBL8715621 | 0.77 | ERN1 (0.47) | MEN1KMT2ALMNAKCNMA1HTT | |
| SCHEMBL8715276 | 0.75 | EGLN2 (0.39) | MEN1KMT2AKCNMA1HPGDGAA | |
| SCHEMBL20567988 | 0.74 | ELANE (0.41) | MEN1KMT2AHPGDGAAGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| CN-1097741-A | Pyridine derivate, Preparation Method And The Use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | CN | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |