Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651719 | 0.82 | TBXAS1 (0.43) | MAPTKDM4EMEN1KMT2APTGS2 | |
| SCHEMBL6651712 | 0.82 | TBXAS1 (0.43) | MAPTKDM4EMEN1KMT2APTGS2 | |
| SCHEMBL16288430 | 0.81 | NQO1 (0.56) | MAPTKDM4EALDH1A1TSHRKMT2A | |
| SCHEMBL12567393 | 0.78 | RELA (0.53) | MAPTCYP1A2CYP3A4NQO2PTPN1 | |
| SCHEMBL4693719 | 0.78 | RELA (0.53) | MAPTCYP1A2CYP3A4NQO2PTPN1 | |
| SCHEMBL4693722 | 0.78 | RELA (0.53) | MAPTCYP1A2CYP3A4NQO2PTPN1 | |
| SCHEMBL1164737 | 0.78 | ALDH1A1 (0.61) | MAPTKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL17080933 | 0.78 | MEN1 (0.59) | MEN1KMT2APTGS1TUBB1AHR | |
| SCHEMBL17246786 | 0.78 | LTA4H (0.50) | CYP1A2TSHRMEN1KMT2AAHR | |
| SCHEMBL3589633 | 0.77 | NQO1 (0.50) | MAPTKDM4ETSHRMMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |