Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 3/20 | 0.35 |
| ▸ | F12 | P00748 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044797 | 0.80 | HDAC6 (0.41) | HDAC6KDRSCDNPC1RAB9A | |
| SCHEMBL8709996 | 0.80 | HDAC6 (0.37) | HDAC6KDRSCDNPC1RAB9A | |
| SCHEMBL8714250 | 0.74 | MAPK9 (0.44) | KMT2ANPC1RAB9AMAPTNPSR1 | |
| SCHEMBL8045484 | 0.73 | HDAC6 (0.57) | HDAC6KDRSCDKMT2ANPC1 | |
| SCHEMBL8033612 | 0.71 | HDAC6 (0.43) | HDAC6KDRSCDNPC1RAB9A | |
| SCHEMBL31680549 | 0.70 | MMP2 (0.54) | HDAC6KMT2ANPC1RAB9AMMP2 | |
| SCHEMBL8032616 | 0.69 | SMN1; SMN2 (0.54) | HDAC6KDRKMT2ANPC1RAB9A | |
| SCHEMBL8032385 | 0.69 | ALDH1A1 (0.48) | HDAC6KDRKMT2ANPC1RAB9A | |
| SCHEMBL2664555 | 0.69 | HCAR3 (0.55) | KMT2ANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8051066 | 0.68 | RAB9A (0.44) | HDAC6NPC1RAB9AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |