Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305010 | 0.79 | HDAC8 (0.43) | HDAC8LMNANPY1RNPY2RPSEN1 | |
| SCHEMBL8715076 | 0.78 | BRD4 (0.34) | LMNAMAPT | |
| SCHEMBL8714462 | 0.77 | HDAC8 (0.47) | HDAC8LMNANPY1RNPY2RPSEN1 | |
| SCHEMBL8714966 | 0.75 | MTNR1A (0.33) | MAPT | |
| SCHEMBL8307326 | 0.74 | HDAC8 (0.51) | HDAC8LMNANPY1RNPY2RPSEN1 | |
| SCHEMBL9414693 | 0.73 | SMN1; SMN2 (0.36) | LMNANPY1RNPY2RMAPT | |
| Iodide SCHEMBL8720179 | 0.72 | SMN1; SMN2 (0.35) | LMNANPY1RNPY2RMAPT | |
| SCHEMBL8717910 | 0.71 | SMN1; SMN2 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8306283 | 0.71 | LMNA (0.47) | HDAC8LMNANPY1RNPY2RPSEN1 | |
| SCHEMBL8717945 | 0.67 | PDE4B (0.33) | LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |