Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8717945 | 0.92 | PDE4B (0.33) | MTNR1AMTNR1BPDE4BPDE3AABL1 | |
| SCHEMBL9414809 | 0.77 | PDE4B (0.35) | MTNR1AMTNR1BPDE4BPDE3APDE4A | |
| SCHEMBL9414693 | 0.76 | SMN1; SMN2 (0.36) | PDE4BPDE3APDE4APDE4CPDE4D | |
| Iodide SCHEMBL8720179 | 0.75 | SMN1; SMN2 (0.35) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL9414695 | 0.75 | PDE4B (0.35) | MTNR1AMTNR1BPDE4BPDE3APDE4A | |
| SCHEMBL8306755 | 0.74 | MTNR1A (0.37) | MTNR1AMTNR1BPDE4BPDE3APDE4A | |
| SCHEMBL8715076 | 0.74 | BRD4 (0.34) | PDE3APDE3BALDH1A1MEN1MAPT | |
| SCHEMBL8304547 | 0.72 | PDE3B (0.48) | MTNR1AMTNR1BPDE4BPDE3APDE4A | |
| SCHEMBL8718071 | 0.69 | SMN1; SMN2 (0.36) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL8720199 | 0.68 | HTT (0.38) | MTNR1AMTNR1BL3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |