Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720710 | 0.87 | SMN1; SMN2 (0.38) | BRD4SMN1; SMN2ALDH1A1PKMCYP2C9 | |
| SCHEMBL9383997 | 0.80 | NR1H2 (0.35) | BRD4SMN1; SMN2GSPT1DDB1CRBN | |
| SCHEMBL8717910 | 0.79 | SMN1; SMN2 (0.38) | BRD4SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL8714966 | 0.74 | MTNR1A (0.33) | SMN1; SMN2KMT2AALDH1A1MAPTHTT | |
| SCHEMBL10405646 | 0.72 | NR1H2 (0.51) | BRD4SMN1; SMN2PDE3BPDE3ANR1H2 | |
| SCHEMBL9414693 | 0.71 | SMN1; SMN2 (0.36) | SMN1; SMN2KMT2AMAPTLMNAPDE3B | |
| Iodide SCHEMBL8720179 | 0.70 | SMN1; SMN2 (0.35) | SMN1; SMN2KMT2AMAPTLMNAPDE3B | |
| SCHEMBL8715129 | 0.70 | CA1 (0.41) | BRD4SMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8717945 | 0.66 | PDE4B (0.33) | SMN1; SMN2KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL9414927 | 0.66 | PNMT (0.40) | SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |