Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | APEH | P13798 | 1/20 | 0.41 |
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716035 | 0.85 | MAPT (0.47) | MAPTSMN1; SMN2PDE9APDE1CAPEH | |
| SCHEMBL8716034 | 0.85 | MAPT (0.47) | MAPTSMN1; SMN2PDE9APDE1CAPEH | |
| SCHEMBL8717597 | 0.78 | LMNA (0.54) | MAPTPLA2G2ASMN1; SMN2CYP19A1P2RX4 | |
| SCHEMBL8716590 | 0.71 | ALDH1A1 (0.46) | MAPTSMN1; SMN2APEHPPME1MEN1 | |
| SCHEMBL8716592 | 0.71 | ALDH1A1 (0.46) | MAPTSMN1; SMN2APEHPPME1MEN1 | |
| SCHEMBL11560494 | 0.66 | PPME1 (0.55) | MAPTSMN1; SMN2APEHPPME1MEN1 | |
| SCHEMBL11560496 | 0.66 | PPME1 (0.55) | MAPTSMN1; SMN2APEHPPME1MEN1 | |
| SCHEMBL8713370 | 0.65 | MAPT (0.66) | MAPTSMN1; SMN2MEN1KMT2ASNCA | |
| SCHEMBL399996 | 0.65 | HTT (0.80) | MAPTSMN1; SMN2MEN1KMT2ASNCA | |
| SCHEMBL8713366 | 0.65 | MAPT (0.66) | MAPTSMN1; SMN2MEN1KMT2ASNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843660-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-05-27 | — | — | EP | claimed |
| WO-1997005109-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-02-13 | — | — | WO | claimed |
| US-5783575-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1998-07-21 | — | — | US | disclosed |
| EP-0843660-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-05-27 | — | — | EP | disclosed |
| US-5696148-A | POTENT ANTAGONIST OF METABOTROPIC GLUTAMATE RECEPTORS; TREATING EPILEPSY, PARKINSON'S DISEASE, HUNTINGTON'S DISEASE, BRAIN DISORDER AND ALZHEIMER'S DISEASE | NOVO NORDISK A/S (DK) | 1997-12-09 | — | — | US | disclosed |
| WO-1997005109-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-02-13 | — | — | WO | disclosed |