Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716090 | 0.82 | KCNA5 (0.40) | SMN1; SMN2LMNAALDH1A1MITFHIF1A | |
| SCHEMBL8718165 | 0.79 | LMNA (0.40) | SMN1; SMN2LMNAALDH1A1ATMNPSR1 | |
| SCHEMBL8718189 | 0.77 | ALDH1A1 (0.39) | SMN1; SMN2LMNAALDH1A1ATMNPSR1 | |
| SCHEMBL8715420 | 0.74 | HDAC8 (0.52) | SMN1; SMN2LMNAMAPTTP53KCNA5 | |
| SCHEMBL8718162 | 0.72 | L3MBTL1 (0.38) | SMN1; SMN2ALDH1A1ATMNPSR1CYP3A4 | |
| SCHEMBL8719002 | 0.71 | L3MBTL1 (0.37) | SMN1; SMN2ALDH1A1HIF1AATMNPSR1 | |
| SCHEMBL26282473 | 0.69 | NTSR1 (0.52) | SMN1; SMN2LMNAALDH1A1MITFHIF1A | |
| SCHEMBL3973868 | 0.69 | HTR2A (0.47) | SMN1; SMN2ALDH1A1CYP3A4CYP2C19MAPT | |
| SCHEMBL3977324 | 0.67 | CRBN (0.42) | SMN1; SMN2LMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL31154521 | 0.67 | MEN1 (0.47) | SMN1; SMN2LMNAALDH1A1MITFHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |