SCHEMBL8716465

SCHEMBL8716465

Cc1cc(O)cc(C)c1NC=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.46
CHRM1 P11229 1/20 0.46
ALOX15 P16050 1/20 0.46
MAOA P21397 1/20 0.46
TBXA2R P21731 1/20 0.46
ADRA1A P35348 1/20 0.46
HTR2B P41595 1/20 0.46
CYTH2 Q99418 5/20 0.43
ACHE P22303 2/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
HTT P42858 1/20 0.36
GAA P10253 1/20 0.34
RAPGEF4 Q8WZA2 1/20 0.33
HSP90AA1 P07900 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2093540 0.81 RAPGEF4 (0.52) KMT2AALDH1A1LMNARAPGEF4
SCHEMBL25732294 0.78 S1PR4 (0.35) ACHEALDH1A1KDM4ELMNAMAPT
SCHEMBL7531476 0.77 ALDH1A1 (0.39) ALDH1A1MAPTHPGDRAPGEF4
SCHEMBL16520251 0.77 HMGB1 (0.38) ALDH1A1RAPGEF4
SCHEMBL10501503 0.77 ALDH1A1 (0.36) ALDH1A1RAPGEF4
SCHEMBL3599664 0.77 ACHE (0.34) CYP3A4ALOX15ACHEMEN1KMT2A
SCHEMBL18535305 0.77 TPMT (0.45) ALOX15MEN1KMT2AALDH1A1KDM4E
SCHEMBL19043755 0.77 KDM5A (0.37) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL3557571 0.76 ALDH1A1 (0.38) CYP3A4ACHEMEN1KMT2AALDH1A1
SCHEMBL10500612 0.74 FFAR4 (0.47) CYP3A4CYTH2MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5770772-A 4-FORMYLAMINO-2,3,5-TRIMETHYL-1-(2-METHYL-2-PROPENYLOXY) -BENZENE; ARTERIOSCLEROSIS, BRAIN AND CARDIOVASCULAR DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-06-23 US disclosed
US-5594154-A 5-AMINO-2-BROMOMETHYL-2,4,6,7-TETRAMETHYL-2,3-DIHYDROBENZO(B) FURANS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-01-14 US disclosed
US-5478844-A Method of using aminocoumaran derivatives for treating cerebrovascular diseases TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-12-26 US disclosed
EP-0483772-B1 Aminocoumaran derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1995-09-13 EP disclosed
US-5376681-A Aminocoumaran derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-12-27 US disclosed
EP-0483772-A1 Aminocoumaran derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-05-06 EP disclosed
EP-0121972-B1 N-ARYL-ALPHA-AMINO-CARBOXAMIDES JANSSEN PHARMACEUTICA N.V. (BE) 1989-05-24 EP disclosed
EP-0121972-A2 N-aryl-alpha-amino-carboxamides JANSSEN PHARMACEUTICA N.V. (BE) 1984-10-17 EP disclosed