Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716772 | 0.88 | HSD11B1 (0.51) | HSD11B1HTR2AHTR2CDRD2LMNA | |
| SCHEMBL8713352 | 0.87 | HSD11B1 (0.52) | HSD11B1HTR2AHTR2CDRD2LMNA | |
| SCHEMBL8711674 | 0.87 | HSD11B1 (0.54) | HSD11B1HTR2AHTR2CDRD2LMNA | |
| SCHEMBL8712025 | 0.85 | CYP2D6 (0.49) | HSD11B1LMNAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8711533 | 0.84 | HSD11B1 (0.49) | HSD11B1HTR2AHTR2CDRD2ALDH1A1 | |
| SCHEMBL8710827 | 0.83 | HSD11B1 (0.54) | HSD11B1HTR2AHTR2CDRD2LMNA | |
| SCHEMBL8716656 | 0.83 | HSD11B1 (0.54) | HSD11B1HTR2AHTR2CDRD2LMNA | |
| Hydrochloric Acid SCHEMBL8711167 | 0.82 | HSD11B1 (0.53) | HSD11B1HTR2AHTR2CDRD2LMNA | |
| Hydrochloric Acid SCHEMBL9229278 | 0.82 | HSD11B1 (0.53) | HSD11B1HTR2AHTR2CDRD2LMNA | |
| SCHEMBL8716461 | 0.82 | HSD11B1 (0.55) | HSD11B1HTR2AHTR2CDRD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |