Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.43 |
| ▸ | HTR2C | P28335 | 7/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1E | P28566 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7775075 | 0.78 | HTR2A (0.43) | HTR2AHTR2CDRD2KCNH2ROCK2 | |
| SCHEMBL8470311 | 0.77 | METAP2 (0.40) | ROCK2ROCK1METAP2TDO2 | |
| SCHEMBL24127329 | 0.69 | DRD2 (0.47) | HTR2AHTR2CDRD2KCNH2HTR2B | |
| SCHEMBL22619200 | 0.69 | NOS1 (0.44) | METAP2 | |
| SCHEMBL17738576 | 0.67 | JAK2 (0.51) | METAP2JAK2JAK1TYK2JAK3 | |
| SCHEMBL2781869 | 0.66 | SLC6A4 (0.56) | HTR2AHTR2CDRD2KCNH2HTR2B | |
| SCHEMBL30403358 | 0.65 | METAP2 (0.56) | METAP2TDO2 | |
| SCHEMBL3538351 | 0.65 | METAP2 (0.56) | METAP2TDO2 | |
| SCHEMBL14028515 | 0.65 | IKBKB (0.58) | ROCK2ROCK1 | |
| SCHEMBL23469324 | 0.64 | HTR2A (0.48) | HTR2AHTR2CDRD2KCNH2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776963-A | ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-07 | — | — | US | disclosed |