Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP14 | P54578 | 5/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407571 | 0.91 | SIGMAR1 (0.37) | USP14HRH2HRH1HRH3SIGMAR1 | |
| SCHEMBL8410942 | 0.89 | USP14 (0.43) | USP14HRH2HRH1HRH3CYP11B1 | |
| SCHEMBL8717927 | 0.85 | USP30 (0.36) | HRH2HRH1HRH3SIGMAR1KDM1A | |
| SCHEMBL8720195 | 0.80 | KDM1A (0.36) | USP14KDM1A | |
| SCHEMBL7753345 | 0.78 | USP14 (0.52) | USP14SIGMAR1FFAR4DPP4 | |
| SCHEMBL8409444 | 0.77 | POLB (0.38) | HRH2HRH1HRH3CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL8714669 | 0.77 | LTA4H (0.33) | HRH3 | |
| SCHEMBL8719948 | 0.73 | KDM1A (0.49) | USP14HRH2HRH1HRH3SIGMAR1 | |
| SCHEMBL9416137 | 0.70 | USP14 (0.48) | USP14HRH2HRH1HRH3SIGMAR1 | |
| SCHEMBL29013541 | 0.69 | FFAR4 (0.46) | USP14FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |