Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851155 | 0.84 | MEN1 (0.38) | KMT2AMEN1 | |
| SCHEMBL8321793 | 0.83 | TDP1 (0.52) | CTSBTDP1ALDH1A1ARRECQL | |
| SCHEMBL3349131 | 0.81 | ALDH1A1 (0.51) | TDP1ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL3615001 | 0.81 | MAPT (0.52) | CTSBTDP1ALDH1A1MAPTLMNA | |
| SCHEMBL15759369 | 0.81 | PTPN1 (0.41) | TDP1PTPN1ALDH1A1MAPTLMNA | |
| SCHEMBL8321796 | 0.80 | CTSB (0.53) | CTSBTDP1ALDH1A1ARMAPT | |
| SCHEMBL8321794 | 0.80 | CTSB (0.53) | CTSBTDP1ALDH1A1ARMAPT | |
| SCHEMBL23112265 | 0.79 | PTPN1 (0.48) | TDP1PTPN1ALDH1A1MAPTLMNA | |
| SCHEMBL9470141 | 0.79 | GPR3 (0.37) | KMT2AMEN1 | |
| SCHEMBL3555143 | 0.79 | MAPT (0.39) | PTPN1ALDH1A1MAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773057-B2 | Naphthalenesulfonamide compound, preparation method, and application | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2023-10-03 | — | — | US | disclosed |
| US-11773057-B2 | Naphthalenesulfonamide compound, preparation method, and application | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2023-10-03 | — | — | US | disclosed |
| US-11773057-B2 | Naphthalenesulfonamide compound, preparation method, and application | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2023-10-03 | — | — | US | disclosed |
| EP-3978471-B1 | NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION | UNIV CHINA PHARMA (CN) | 2023-02-22 | — | — | EP | disclosed |
| EP-3978471-B1 | NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION | UNIV CHINA PHARMA (CN) | 2023-02-22 | — | — | EP | disclosed |
| US-20220251035-A1 | NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2022-08-11 | — | — | US | disclosed |
| EP-3978471-A1 | NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION | China Pharmaceutical University (CN) | 2022-04-06 | — | — | EP | disclosed |
| EP-3978471-A1 | NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION | China Pharmaceutical University (CN) | 2022-04-06 | — | — | EP | disclosed |
| WO-2021012721-A1 | NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION | 中国药科大学 | 2021-01-28 | — | — | WO | disclosed |
| CN-108101821-B | Naphthyl sulfonamide amino acid derivative, preparation method and medical application thereof | 中国药科大学 | 2020-11-20 | — | — | CN | disclosed |
| CN-110256305-B | Naphthalene sulfonamide compound, preparation method and application | 中国药科大学 | 2020-05-26 | — | — | CN | disclosed |
| WO-1998035982-A1 | COMPOUNDS FOR USE IN ADEPT | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773057-B2 | Naphthalenesulfonamide compound, preparation method, and application | NFE2L2, KEAP1, NFE2 | CTSB 462/4885TDP1 4816/4885PTPN1 3417/4885 |
| US-20220251035-A1 | NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION | NFE2L2, KEAP1, NFE2 | CTSB 462/4885TDP1 4816/4885PTPN1 3417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.