Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 14/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5269933 | 0.90 | SLC6A9 (0.71) | SLC6A9SLC6A4HRH3NPC1CYP2D6 | |
| SCHEMBL8726597 | 0.89 | SLC6A9 (0.57) | SLC6A9SLC6A4HRH3HTR1ANPC1 | |
| SCHEMBL7943023 | 0.85 | SLC6A9 (0.72) | SLC6A9SLC6A4HRH3NPC1CYP2D6 | |
| SCHEMBL8931276 | 0.84 | SLC6A4 (0.64) | SLC6A9SLC6A4HRH3HTR1ANPC1 | |
| SCHEMBL8726521 | 0.83 | SLC6A9 (0.63) | SLC6A9SLC6A4HRH3HTR1ANPC1 | |
| SCHEMBL13780465 | 0.81 | SLC6A9 (0.77) | SLC6A9SLC6A4HRH3NPC1CYP2D6 | |
| SCHEMBL7939788 | 0.81 | SLC6A9 (0.69) | SLC6A9SLC6A4HRH3NPC1CYP2D6 | |
| SCHEMBL8204423 | 0.80 | SLC6A9 (0.60) | SLC6A9SLC6A4HRH3NPC1CYP2D6 | |
| SCHEMBL8931267 | 0.79 | ALDH1A1 (0.44) | SLC6A9SLC6A4HTR1AACHE | |
| SCHEMBL8722262 | 0.79 | SLC6A9 (0.67) | SLC6A9SLC6A4HRH3NPC1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0617006-B1 | N-Substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and procedure for their preparation | PLIVA PHARM & CHEM WORKS (HR) | 1998-05-06 | — | — | EP | disclosed |
| US-5618968-A | N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation | PLIVA FARMACEUTSKA KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA, DIONICKO DRUSTVO (HR) | 1997-04-08 | — | — | US | disclosed |
| EP-0617006-A1 | N-subtituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation | PLIVA d.d. ZAGREB (HR) | 1994-09-28 | — | — | EP | disclosed |